Marek Michalak

Distinguished University Professor

Department of Biochemistry, University of Alberta

Adjunct Professor

Department of Biochemistry & Molecular Biology

Molecular Biology and Disease

Ph.D. (Doctor of Philosophy)


Contact information

Location

University of Alberta, Department of Biochemistry : Medical Science Building, 114 Street, Edmonton, AB 3-55

Research and teaching

Research Activities

Our lab studies the structure and function of endoplasmic reticulum (ER) membranes and the role of this membrane system in the control of intracellular signalling, communication with other intracellular organelles, regulation of protein synthesis and folding, modulation of gene expression and calcium homeostasis. The ER plays a vital role in many cellular processes, including calcium signaling lipid biosynthesis; and protein synthesis, folding, and post-translational modification. Most importantly, the ER can detect and integrate incoming signals, generate output signals in response to environmental changes, and can even modulate its own luminal dynamics. How the ER affects the balance between anti- versus pro-apoptotic signals, and therefore between adaptive and maladaptive cellular responses, remains a crucial question in pathophysiology and in cell biology. ER stress is associated with many severe human pathologies including heart disease, metabolic disorders, cancer and neuropathies. The multifunctional nature of the ER has enabled us to help identify the contribution of several ER associated proteins to the maintenance of ER homeostasis in health and disease. We discovered that ER resident chaperones play critical roles in cardiac development and pathophysiology of the mature heart. The proteins are also key in specific neuropathies. Currently, the focus of our lab is on the role of ER associated molecular chaperones (calreticulin, calnexin and others) and ER stress in cardiac and nervous system physiology and pathophysiology. Our long-term goal is to understand ER stress and ER signaling events responsible for the activation and maintenance of intracellular pathways affecting cardiac or neuronal physiology and pathology, and to use this information to devise pharmacological and genetic therapies for the treatment of human disease.

Research Areas: 

Molecular Biology and Disease


Publications

PubMed