Inflammatory Brain Diseases Research Program - BrainWorks

An international, multi-centre precision medicine program that aims to increase recognition, transform care and optimize outcomes for children and adults living with CNS vasculitis and inflammatory brain diseases.

 

Clinicians:

Dr. Katayoun Alikhani

Dr. Susanne Benseler, Program Lead

Dr. Jeff Buchhalter

Dr. Michael Esser

Dr. Aurora Fifi-Mah

Dr. Adam Kirton

Dr. Aleksandra Mineyko

Dr. Marinka Twilt

Program Coordinators:

Jeanie Quach, Research Coordinator

Blake Farion, Research Coordinator

Research Staff:

Ashley Choo

Brianna Ghali

Robin Hao

Jordan Kelly

Tanya Siddiqui

Doctors around the world caring for children and adults with inflammatory brain disease have teamed up with basic science researchers, families, medical specialists and supportive organizations to establish the web-based, password secured innovative registry BrainWorks. BrainWorks is an international prospective cohort of patients with brain inflammation treated with standardized treatment protocols and assessed using standardized outcome measures.

Active Research:

Biomarker Research:

  • von Willebrand Factor antigen: predicting disease activity in childhood CNS vasculitis
  • Development of histopathology diagnostic approach and biomarkers in childhood small vessel vasculitis
  • Biomarker discovery in inflammatory brain diseases
  • Inflammatory pathways in brain biopsies of children with CNS vasculitis

Long-term Outcomes Research:

  • Predictors of quality of life in childhood inflammatory brain disease
  • Long-term cognitive outcomes in childhood CNS vasculitis
  • Comparative effectiveness research: treatment of CNS vasculitis

Knowledge Translation: