COVID-19 Research Studies

The Calgary Critical Care Research Network investigators are leading several COVID-19 studies. These studies are led by Drs. Parsons Leigh, Parhar, Fiest, Stelfox, Weatherald and Niven. Thank you to the Canadian Institutes of Health Research, Research Nova Scotia and the University of Calgary for funding this work. 

COVID-19 Research Studies

The Calgary Critical Care Research Network investigators are leading several COVID-19 studies. These studies are led by Drs. Parsons Leigh, Parhar, Fiest, Stelfox, Weatherald and Niven. Thank you to the Canadian Institutes of Health Research, Research Nova Scotia and the University of Calgary for funding this work. 

 

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Study Description

We are investigating how restricted visitation policies have affected ICU patients, family members of patients, healthcare providers, administrators and decision makers in Canadian ICUs across Canada. 

We assembled a multidisciplinary team with clinicians, researchers, patient partners and knowledge users across Canada. Using a phased approach we aim to create evidence-informed consensus statements.

You can follow the study's social media channels to keep up to date with new updates on our study. Follow us on twitter: @ICU_Visitation or instagram @icu_covid_visitation

Study Overview

Phase 1: Environmental Scan

Our team collected, coded and analyzed 313 visitation policies from hospitals and ICUs across Canada. With the results of the environmental scan, the team will describe the variation and extent of restricted visitation policies at Canadian hospitals (academic & community) at multiple points throughout the COVID-19 pandemic.

Phase 2: Virtual Interviews

To gain an understanding of the personal impact of restricted visitation policies on patients, family members, healthcare providers, administrators and decision makers in ICUs across Canada during COVID-19, we interviewed 34 healthcare providers/decision makers and 11 patients/family members. The semi-structured interviews were coded and analyzed. The results will be used to develop recommendations and inform the next phase.

Phase 3: National Stakeholder Meeting

We will be generating national evidence-informed consensus statement on restricted visitation policies informed by patients, families, healthcare providers and decision makers' experiences. The process will include ranking priorities for policies identified in interviews & discussing recommendations for future policies through a remote modified Delphi consensus process followed by a National stakeholder meeting in the upcoming months.

Study Description

We are investigating the impact of COVID-19 on healthcare providers and health systems globally. We are recruiting critical care physicians as well as physicians who have been deployed to one of these specialities during the pandemic. 

Physicians will be asked to participate in a 30-minute telephone interview to speak about 1) the capacity of their health system to respond to COVID-19 and 2) the impact of COVID-19 on their professional and personal lives. The data will inform government and health system responses to infectious disease outbreaks. 

If you are interested in participating, please email us at C3ResNetwork@ucalgary.ca and we will schedule an interview at the time that best suits your schedule. 

Study Overview

Study Objective

Understand the impact of COVID-19 on healthcare providers and health systems globally

Study Eligibility

Critical Care Physicians

Physicians deployed to the above specialties

Next Steps

Email: C3ResNetwork@ucalgary.ca

Choose a 30 minute time slot that works best for your study interview

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Study Description

Background: On March 11, 2020 the World Health Organization declared the COVID-19 disease outbreak a global pandemic. Approximately 14% of people infected with SARS-COV-2 will develop severe disease that requires hospitalization, and 5% require admission to an intensive care unit (ICU). In severe cases, COVID-19 can be complicated by acute respiratory distress syndrome (ARDS), which carries a high risk of death. Most patients with ARDS require intubation and mechanical ventilation in the ICU. Prone positioning (PP) for >12-16 hours per day reduces mortality by approximately 26% in mechanically ventilated patients with ARDS. It stands to reason that the benefits of PP in hypoxemic respiratory failure patients would hold true in those who are not receiving mechanical ventilation. The possible benefits of PP for non-mechanically ventilated patients include:

  1. Reduced atelectasis of dependant posterior lung regions
  2. Improved oxygenation through better ventilation / perfusion matching
  3. Reduced work of breathing from improved lung compliance
  4. Reduced self induced lung injury from large pleural pressure swings
  5. Improved secretion clearance from dependant lung regions.

There have been no prior randomized studies evaluating PP for non-intubated patients on regular hospital wards, where the majority of affected COVID-19 patients will be treated. There are currently no other registered randomized controlled trials evaluating PP during the COVID-19 pandemic.

Objective: Determine whether PP improves clinical outcomes for non-intubated hospitalized patients with hypoxemic respiratory failure due to COVID-19. We hypothesize that PP will reduce in-hospital mortality compared with usual care for non-intubated patients with hypoxemic respiratory failure due to COVID-19.

Design & Setting: This will be a multi-centre, open-label randomized trial at 4 hospitals in Calgary, Alberta comparing PP to usual care. This study will inform the scale up to additional hospital sites across Alberta.

Population: 

  • Inclusion Criteria: Adult patients with confirmed or suspected COVID-19 admitted to Calgary hospitals will be enrolled if they provide verbal consent, are physically capable of self positioning into PP and require more than 2L of oxygen to maintain saturations >92%. 
  • Exclusion Criteria: Patients will be excluded if they are admitted directly to the ICU or have hemodynamic instability, cardiogenic pulmonary edema, hypercapnic respiratory failure (PaCO2>45 mmHg), decreased level of consciousness, are unable to reposition themselves, or have other contraindications to prolonged PP (i.e. pregnancy, recent surgery).

Intervention and Standard Care Groups: The intervention group will receive instructions to assume a PP four times per day from nursing staff and respiratory therapists. Adherence and changes in oxygenation 5-10 min after PP will be recorded. The targeted duration of PP is ≥8 hours per day. Patients will be asked to self-position in a PP for 2-hour sessions, four-times per day during the day. The standard care group will receive usual medical care without prompting to assume a PP.

Study Description

We investigated the impact of COVID-19 on Intensive Care Units (ICU’s) and ICU physicians. Canadian Critical Care physicians participated in brief, semi-structured, telephone interviews and spoke about 1) perceived factors affecting the capacity of ICUs to manage patient with COVID-19 2) personal and professional implications of working during an infectious disease outbreak.

Study Objective

Explore critical care physicians’ perceptions, experiences and implications of resource strain in the context of caring for critically ill patients with COVID-19, including implications for patient care, and the impact on physicians; professional and personal lives.

Eligibility

ICU physician working in Canadian Universities with adult critical care training programs.

Next Steps

We are currently in the process of submitting this manuscript for publication. Future work in this area will include a longitudinal component of the changing impacts on healthcare providers during the COVID-19 pandemic and how strategies to ameliorate and manage negative impacts.

Study Description:

Worldwide spread of the novel coronavirus that causes COVID-19 has been fast and severe. Frequent updates from government, health, and social media help keep the public informed. Yet, the spread of misleading and incorrect information is also common. Incomplete information can negatively impact how individuals and communities respond to the outbreak. Our research team conducted a national survey (April 26 to May 1st) to identify and understand the many factors that may be influencing Canadians actions and reactions to this pandemic. 

 

 

Study Objectives

Capture a broad snapshot of public perceptions, knowledge, and behaviors related to the COVID-19 pandemic.

 

Study Eligibility

  • Adult (18 years or older)
  • Reside in Canada
  • Read English or French
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Next Steps

  1. Data collection is completed (access aggregate study findings)
  2. One manuscript submitted for publication and second manuscript in development
  3. Further explore survey results (click to complete questionnaire to participate in other studies)