Douglas Storey

Associate Member

Douglas Storey

Douglas Storey

Professor, Biological Sciences

Biological Sciences (BI)

Division of Cellular, Molecular, and Microbial Biology (CMMB)

Adjunct Professor, Microbiology, Immunology & Infectious Diseases (MIID)

Address: 196A Biological Science Building

Phone: (403) 220-5274/(403) 220-3574 (lab)

Email:  storey@ucalgary.ca

 

Curriculum Vitae

  • B.Sc. University of British Columbia, 1978
  • MSc University of Western Ontario, 1981
  • PhD University of Ottawa, 1986
  • Post-doctoral Fellowship--Department of Microbiology & Immunology, Rochester Medical School, 1989

Research

My research interests focuses on two bacteria, Pseudomonas aeruginosa and Burkholderia cepacia, that cause severe and life threatening infections in individuals with the genetic disease cystic fibrosis. My studies focus on the regulation, communication and coordination of molecular, genetic and population responses of these bacteria during infections. Our ultimate goal is to develop new antimicrobial treatments to eliminate these infections in individuals with cystic fibrosis .

Research In Progress

There are four main projects being pursued in my laboratory.

  • The role of the Pseudomonas aeruginosa two component regulatory system GacA/S in biofilm formation and virulence.
  • The regulation of Pseudomonas aeruginosa virulence factors in the lungs of individuals with CF.  In particular I am interested in the role of quorum sensing systems and other global regulatory systems in the development of the infection
  • The pathogenomics of Burkholderia cepacia. I am interested in the association between biofilm formation and virulence in this bacterium
  • The genetics and regulation of biofilm formation

Research

 Analysis of genome structure in enteric bacteria. Study of plasmids and of conjugation in enteric bacteria (Salmonella and Escherichia). Recombinant DNA methods. Genetics and biochemistry of the enteric bacteria. Structure and synthesis of the cell envelope of Gram-negative bacteria, especially the lipopolysaccharide.

 

Research in Progress

  • Use of pulsed-field gel electrophoresis in analysis of the genomes of enteric bacteria.

    Use of recombinant DNA methods in studying genetics of Salmonella typhimurium .

    Maintenance of the Salmonella Genetic Stock Centre

    Study of the chromosomes of Salmonella typhimurium ,S. typhi and other species of Salmonella

    Analysis of the genetic basis for virulence in Salmonella.

     

People

Graduate Students:

    • Ph.D.
      Erika Lutter
      Stefanie Schienmann

      M.Sc.
      Joan St. Armand
      Kasia Stevens

    • Ph.D.
      Erika Lutter
      Stefanie Schienmann

      M.Sc.
      Joan St. Armand
      Kasia Stevens