Past Publications
Our team has contributed to the following publications
2018
A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, a single-dose clinical trial of a new class of bronchodilator for acute asthma
Between-visit variability in FEV1 as a diagnostic test for asthma in adults
Severe, eosinophilic asthma in primary care in Canada: a longitudinal study of the clinical burden and economic impact based on linked electronic medical record data
Sex differences in outcomes after discharge from Alberta emergency departments for asthma: a large population-based study
2017
Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study
Chronic cough is predominantly a woman's issue
Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD
Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients
2016
Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial
Long-term efficacy and safety of mepolizumab in patients with severe eosinophilic asthma: a multi-center, open-label, phase IIIb study
A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers
A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma
Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses
Blood flow during handgrip exercise in COPD: effect of vitamin C
An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti- and proinflammatory effector genes
Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study
2015
Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration
Cerebrovascular and ventilatory responses to acute isocapnic hypoxia in healthy aging and lung disease: effect of vitamin C
Empowering family physicians to impart proper inhaler teaching to patients with chronic obstructive pulmonary disease and asthma
Rhinovirus in the pathogenesis and clinical course of asthma
Virus-induced modulation of lower airway diseases: pathogenesis and pharmacological approaches to treatment
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial
A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses
Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study
2014
Effects of an anti-TSLP antibody on allergen-induced asthmatic responses
Identification and validation of nebulized aerosol devices for sputum induction
Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma
Mepolizumab treatment in patients with severe eosinophilic asthma
Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production
Safety and efficacy or an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial
Disconnect between sputum neutrophils and other measures of airway inflammation in asthma
2013
Establishing a normal range for induced sputum cell counts in Western Canada
A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma
A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy
Effects of benralizumab on airway eosinophils in asthmatic patient with sputum eosinophilia
TNAα antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial
2012
Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes
Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone
Periostin in a systematic biomarker of eosinophilic airway inflammation in asthmatic patients
Cytologic assessment of endobronchial ultrasound-guided transbronchial needle aspirates in sarcoidosis
Canadian Thoracic Society 2012 guideline update: diagnosis and management of asthma in preschoolers, children and adults
Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide
2011
β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids
Effects of a short course of inhaled corticosteroids in noneosinophilic asthmatic subjects
Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study
Epithelial cells and airway diseases