Calgary Normative Study

The Calgary Normative Study (CNS) is an ongoing, longitudinal study of normal human brain aging which focuses on acquiring quantitative MR imaging structural and functional data. The CNS began in 2014 and to date over 475 subjects have been enrolled (18-90+ years) with over 250 subjects having had follow-up imaging after a period of approximately 3.5 and 7.0 years. We anticipate enrolling additional subjects and acquiring follow up data at 10.5 years and later.

Each subject receives an imaging battery (including T1 morphology, perfusion and diffusion imaging, resting state fMRI, quantitative susceptibility mapping), resting-state fMRI and T1 and T2 relaxometry, plus a simple cognitive test, short neuropsychological assessment, and acquisition of a medical history. See our "protocol" paper:

• McCreary CR, Salluzzi M, Andersen LB, Gobbi D, Lauzon ML, Saad F, Smith EE, Frayne R. Calgary Normative Study: Design of a Prospective Longitudinal Study to Characterise Potential Quantitative MR Biomarkers of Neurodegeneration over the Adult Lifespan. BMJ Open 2020; 10: e038120.