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Peer Reviewed Publications

2024

Zheng J, Baimoukhametova D, Lebel D, Kurrasch D. Hypothalamic vasopressin sex differentiation is observed by embryonic day 15 in mice and is disrupted by the xenoestrogen bisphenol A. Proceedings of the National Academy of Sciences. 2024 May 16; 121 (21) e2313207121. doi: https://doi.org/10.1073/pnas.2313207121

2023

Fong H, Zheng J, Kurrasch D. The structural and functional complexity of the integrative hypothalamus. Science. 2023 Oct 27;382(6669):388-394. doi: 10.1126/science.adh8488. Epub 2023 Oct 26. PMID: 37883552.

Lessey AJ, Mirczuk SM, Chand AN, Kurrasch DM, Korbonits M, Niessen SJM, McArdle CA, McGonnell IM, Fowkes RC. Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development. Int J Mol Sci. 2023 Aug 18;24(16):12921. doi: 10.3390/ijms241612921. PMID: 37629102; PMCID: PMC10454581.

Dogra D, Meza-Santoscoy PL, Gavrilovici C, Rehak R, de la Hoz CLR, Ibhazehiebo K, Rho JM, Kurrasch DM. kcna1a mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and show response to first-line therapy carbamazepine. Epilepsia. 2023 Aug;64(8):2186-2199. doi: 10.1111/epi.17659. Epub 2023 Jun 4. PMID: 37209379.

George AG, Farrell JS, Colangeli R, Wall AK, Gom RC, Kesler MT, Rodriguez de la Hoz C, Villa BR, Perera T, Rho JM, Kurrasch D, Teskey GC. Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia. Neuropharmacology. 2023 Jun 15;231:109513. doi: 10.1016/j.neuropharm.2023.109513. Epub 2023 Mar 21. PMID: 36948357.

Lacroix R, Kurrasch DM. Glyphosate Toxicity: In Vivo, In Vitro, and Epidemiological Evidence. Toxicol Sci. 2023 Mar 1:kfad018. doi: 10.1093/toxsci/kfad018. Epub ahead of print. PMID: 36857578.

Fong H, Kurrasch DM. Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia. Front Neurosci. 2023 Jan 20;16:1129414. doi: 10.3389/fnins.2022.1129414. PMID: 36741057; PMCID: PMC9895379.

2022

Ghazale H, Park E, Vasan L, Mester J, Saleh F, Trevisiol A, Zinyk D, Chinchalongporn V, Liu M, Fleming T, Prokopchuk O, Klenin N, Kurrasch D, Faiz M, Stefanovic B, McLaurin J, Schuurmans C. Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo. Front Neurosci. 2022 Aug 18;16:917071

Zheng J, Reynolds JE, Long M, Ostertag C, Pollock T, Hamilton M, Dunn JF, Liu J, Martin J, Grohs M, Landman B, Huo Y, Dewey D, Kurrasch D, Lebel C. The effects of prenatal bisphenol A exposure on brain volume of children and young mice. Environ Res. 2022 Nov;214(Pt 3):114040. 

Rosin JM, Tretiakov N, Hanniman E, Hampton K, Kurrasch DM. Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups. Front Neurosci. 2022 Feb 18;16:830399.

2021

Han S, Okawa S, Wilkinson GA, Ghazale H, Adnani L, Dixit R, Tavares L, Faisal I, Brooks MJ, Cortay V, Zinyk D, Sivitilli A, Li S, Malik F, Ilnytskyy Y, Angarica VE, Gao J, Chinchalongporn V, Oproescu AM, Vasan L, Touahri Y, David LA, Raharjo E, Kim JW, Wu W, Rahmani W, Chan JA, Kovalchuk I, Attisano L, Kurrasch D, Dehay C, Swaroop A, Castro DS, Biernaskie J, Del Sol A, Schuurmans C. Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding. Neuron. 2021 Sep 15;109(18):2847-2863.e11. 

Rosin JM, Malik F, Kurrasch DM. Live-cell imaging of microglial interactions with radial glia in transgenic embryonic mouse brains using slice culture. STAR Protocols, 2021, July 29; 2(3):100670

Nesan D, Feighan KM, Antle MC, Kurrasch DM. Gestational low-dose BPA exposure impacts suprachiasmatic nucleus neurogenesis and circadian activity with transgenerational effects. Sci Adv, 2021 May 28;7(22)

Rosin JM, Sinha S, Biernaskie J, Kurrasch DM. A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors. Dev Cell, 2021 May 3;56(9). Epub 2021 Apr 21

Crane-Smith Z, Schoenebeck J, Graham KA, Devenney PS, Rose L, Ditzell M, Anderson E, Thomson JI, Klenin N, Kurrasch DM, Lettice LA, Hill RE. A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development. Front Cell Dev Biol, 2021 Apr 1;9:595744

Rosin JM, Marsters CM, Malik F, Far R, Adnani L, Schuurmans C, Pittman QJ, Kurrasch DM. Embryonic Microglia Interact with Hypothalamic Radial Glia during Development and Upregulate the TAM Receptors MERTK and AXL following an Insult. Cell Reports, 2021 Jan 5; 34(1):108587

2020

Marsters, CM., Nesan, D, Far, R, Klenin, N, Pittman, QJ, & Kurrasch, DM. Embryonic microglia influence developing hypothalamic glial populations. Journal of Neuroinflammation, 17, 1-17. 2020

Aslanpour, S., Han, S., Schuurmans, C., & Kurrasch, D. M. Neurog2 acts as a classical proneural gene in the ventromedial hypothalamus and is required for the early phase of neurogenesis. Journal of Neuroscience, 40(18), 3549-3563. 2020

Aslanpour, S., Rosin, J. M., Balakrishnan, A., Klenin, N., Blot, F., Gradwohl, G., ... & Kurrasch, D. M. Ascl1 is required to specify a subset of ventromedial hypothalamic neurons. Development, 147(10). 2020

Nesan, D., Thornton, H. F., Sewell, L. C., & Kurrasch, D. M. An Efficient method for generating murine hypothalamic neurospheres for the study of regional neural progenitor biology. Endocrinology, 161(4), bqaa035. 2020.

Ibhazehiebo K, Rho JM, Kurrasch DM. Metabolism-based drug discovery in zebrafish: an emerging strategy to uncover new anti-seizure therapies. Neuropharmacology, 176, 107988. 2020.

Nesan D and Kurrasch DM. Gestational exposure to common endocrine disrupting chemicals and their impact on neurodevelopment and behavior. Annual Review of Physiology,  Feb 10;82:177-202. 2020

2019

Rosin J, Kurrasch DM. Emerging roles for hypothalamic microglia as regulators of physiological homeostasis. Frontiers in neuroendocrinology: 100748, 2019.

2018

Rosin J, Vora SR, Kurrasch DM. Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice weight gain, hyperactivity and anxiolytic-like behavior. Brain, Behavior, Immunity, 73: 682-697, 2018.

Han S, Dennis D, Balakrishnan A, Dixit R, Britz O, Zinyk D, Guillemot F, Kurrasch DM, Schuurmans C. A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis. Development, 149(19): 157719, 2018.

Rosin J, Kurrasch DM. In utero electroporation induces cell death and alters embryonic microglia morphology and expression signatures in the developing hypothalamus. Journal of Neuroinflammation, 15(1):181, 2018.

Rosin J, Kurrasch DM. Bisphenol A and microglia: could microglia be responsive to this environmental contaminant during development? American Journal of Physiology: Endocrinology & Metabolism, 315(2); E279-E285, 2018.

Ibhazehiebo, K., Gavrilovici, C., de la Hoz, C. L., Ma, S. C., Rehak, R., Kaushik, G., Meza Santoscoy, P.L., Scott, L., Nath, N., Kim, D.Y., Rho, J.M., & Kurrasch D.M. A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target. Brain, 141(3), 744-761. Jan 24, 2018.

*Best publication award to K Ibhazehiebo by Canadian League Against Epilepsy, 2018

Nesan, D., Sewell, L. C., & Kurrasch, D. M.  Opening the black box of endocrine disruption of brain development: Lessons from the characterization of Bisphenol A. Hormones and behavior. 101:50-58, 2018.

2017

Basso, L., Lapointe, T. K., Iftinca, M., Marsters, C., Hollenberg, M. D., Kurrasch, D. M., & Altier, C. Granulocyte-colony–stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis. Proceedings of the National Academy of Sciences, PNAS, 114 (42): 11235-11240, 2017

Dennis, D. J., Wilkinson, G., Li, S., Dixit, R., Adnani, L., Balakrishnan, A., ... & Dyck, R. H. Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex. Proceedings of the National Academy of Sciences,PNAS 114(25): E4934, 2017.

Best, Carol, Deborah M. Kurrasch, and Mathilakath M. Vijayan. Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish. Scientific reports 7: 40905. Jan 2017.

2016

Marsters C, Rosin J, Thornton HF, Aslanpour S, Klenin N, Adnani, L, Schuurmans C, Pittman, Q, Kurrasch D.M. Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1. Neural Dev, 11(1):20. Nov 18, 2016.

Nesan, D., & Kurrasch, D. M. Genetic programs of the developing tuberal hypothalamus and potential mechanisms of their disruption by environmental factors. Molecular and cellular endocrinology, 438, 3-17. Oct 2016.

Kinch, C.D., Kurrasch, D.M., Habibi, H.R. Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic Toxicology, 175:286-98. June 2016.

Hanwell D, Hutchinson SA, Bruce AE…Kurrasch DM…Wilson J, Sowden-Plunkett L, Tropepe V. Restrictions on the importation of zebrafish into Canada associated with spring viremia carp virus. Zebrafish,13 Suppl: S153-63, 2016. 

2015

Coughlin G, Kurrasch, D.M. Protocadherins and hypothalamic development: do they play an unappreciated role? Journal of Neuroendocrinology, 27 (6): 544-555, 2015.

Rosin, J. M., Kurrasch, D. M., & Cobb, J.  Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves. BMC neuroscience, 16(1), 39. July 9, 2015.

Rosin, J. M., McAllister, B. B., Dyck, R. H., Percival, C. J., Kurrasch, D. M., & Cobb, J. Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Developmental biology, 399(1), 54-67. March 1, 2015

Kinch, C. D., Ibhazehiebo, K., Jeong, J. H., Habibi, H. R., & Kurrasch, D. M. Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proceedings of the National Academy of Sciences, 112(5), 1475-1480. Feb 3, 2015.

Thornton H.F., Zhang Z.W., Kurrasch, D.M. The genetic underpinnings of Gordon Holmes Syndrome. Journal of Undergraduate Research in Alberta, 4(2), 2015.

2014

Li S, Mattar P, Dixit R, Lawn S, Wilkinson G, Kinch CD, Eisenstat E, Kurrasch DM, Chan JA, and Schuurmans CS. RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis. Journal of Neuroscience, 34(6) 2169-2190, Feb 5, 2014.

Dixit R, Wilkinson G, Cancino G, Shaker T, Adnani L, Li S, Dennis D, Kurrasch DM, Chan JA, Olson E, Kaplan D, Zimmer C, and Schuurmans C. Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. Journal of Neuroscience, 34(2): 539-553, Jan 8 2014.

2013

Lu F, Kar D, Gruenig N, Zhang ZW, Hodges H, Swindell E, Jamrich, M, Mathers P, Kurrasch DM. Rax is a selector gene for hypothalamic feeding circuits. J of Neuroscience Jan 2;33(1):259-272, 2013.

Schuurmans C and Kurrasch DM. Neurodevelopmental Consequences of Maternal Distress: What do we really know? Clinical Genetics, Feb;83(2):108-17, 2013.

Cheung CC, Kurrasch DM, Liang J, Ingraham HA. Genetic labeling of Steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH. J Comp Neurology, 521(6): 1268-1288, 2013.

Kovach C, Dixit R, Li S, Wilkinson G, Mattar P, Elsen G, Kurrasch DM, Hevner R, Schuurmans C. Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex. Cerebral Cortex,23(8), 1884-1900, 2013.

2012

Shaker T, Daniel D, Kurrasch DM, Schuurmans CS. Neurog1 and Neurog 2 coordinately regulate development of the olfactory system. Neural Development, 7:28, 2012.

Li S, Mattar P, Zinuk D, Singh K, Chaturvedi C-P, Kovach C, Kurrasch DM, Ma Y, Chan JA, Wallace VA, Dilworth M, Brand M, Schuurmans C. GSK3beta regulates developmental timing in the neocortex by controlling the cortical determination activity of Neurogenin2. J Neuroscience, 6:32, 7791-805, 2012.

2011

Dixit R, Lu F, Cantrup R, Gruenig N, Kurrasch DM*, Schuurmans, C*. Efficient gene delivery into multiple CNS territories using in utero electroporation. J of Visualized Expts, 52:e2957, 2011. *co-corresponding authors

Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GC, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM. Hepatic Fatty Acid Oxidation Inhibited by RGS16 in a CHREBP-Dependent Manner. J Biol Chemistry, 286: 15116, 2011 (plus cover art).