STAR AF 3

Strategies for Catheter Ablation of Persistent Atrial Fibrillation

Objective

The objective of this study is to compare the efficacy of three different ablation strategies in patients with persistent AF:

  1. PV antral isolation alone (PVAI)
  2. PV antral isolation plus ablation of drivers (PVAI+drivers)
  3. PV antral isolation plus isolation of posterior wall (PVAI+box) 

  1. Inclusion

    • 18 years of age or older
    •  Undergoing first-time ablation procedure for AF
    • Persistent, symptomatic AF (sustained episode >3 months and <3 years
    • Refractory to at least one antiarrhythmic drug
    • AF  documented by ECG, holter, loop recorder, telemetry, trans-telephonic monitor or implanted device within the last 2 years 
    •  Written informed consent 

  2. Exclusion

    • Paroxysmal AF (no episodes lasting > 7 days)
    • Early persistent AF, sustained episode ≤ 3 months
    •  Long term persistent AF (episodes lasting > 3 years)
    •  CHA2DS2-VASc score of 0.
    •  Cardioversion or sinus rhythm will never be attempted/pursued
    •  AF due to an obvious reversible cause
    •  Contraindication to oral anticoagulation or systemic anticoagulation with heparin
    •  Left atrial diameter > 60 mm 
    • Patients who are pregnant
Enrolling

Additional Info

Ethics ID: REB21-0645

ClincalTrials.gov ID: NCT04428944

 

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

 

PI: Dr. Carlos Morillo 

Phone: 403 210 2670

 

Admin: Jennifer McKeage

Phone: 403 210 6047

Email: jmckeage@ucalgary.ca

Updated Jan 18, 2024

ICF v1.5