Wallace MacNaughton
Professor
Contact information
Web presence
Location
Research
Research areas
- Mouse models of colitis and inflammation-induced colon cancer
- Cell culture
- Transfection
- Luciferase reporter assays
- Chromatin immunoprecipitation (ChIP)
- Western blot
- Semi-quantitative and quantitative PCR
- Confocal microscopy
- Ussing chambers (epithelial ion transport)
- Bacterial culture
Research Activities
Our research focuses on the role of the epithelium in health and disease. We are studying how disruptions in epithelial function contribute to conditions such as inflammatory bowel disease (IBD), radiation enteritis and colorectal cancer.
Administrative Assistant
Chloe Fowler
jonec@ucalgary.ca
403-210-7916
Biography
Wally obtained his BSc (1984) and MSc (1986) in Biology from Queen’s University in Kingston, Ontario. After a brief stint as a lab technician at McMaster University and Queen’s, he completed his PhD in Physiology at Queen’s in 1989, under the supervision of Dr. John Wallace. It was in Dr. Wallace’s lab that he developed his interest in the mediators of mucosal healing in inflammatory diseases of the gut. He then did post-doctoral fellowships at University of Calgary, under Dr. Grant Gall, and at the University of Ottawa, under Drs. Tony Krantis and Kent Harding. In 1991, Wally joined the Department of National Defence (Canada) as a Defence Scientist in the Radiation Biology Group, studying the effects of ionizing radiation on intestinal epithelial function, and had adjunct appointments in the Departments of Physiology and Medicine at the University of Ottawa. He joined the Faculty of Medicine at the University of Calgary in 1996, and is currently Professor and Head of the Department of Physiology and Pharmacology in the Cumming School of Medicine. Wally’s current research interests are in intestinal epithelial biology in health and disease, particularly the factors that regulate epithelial restitution and mucosal healing in the Inflammatory Bowel Diseases, Crohn’s disease and ulcerative colitis. His lab has been continuously funded by the Canadian Institutes of Health Research and Crohn’s and Colitis Canada, with additional support from the Natural Sciences and Engineering Research Council and the University of Calgary.