William Cole
Professor
Andrew Family Professor in Cardiovascular Research
Contact information
Location
Office
: HMRBG77
Research
Research areas
- Vascular smooth muscle
- Arterial resistance vessels
- Blood pressure regulation
- Potassium channels
- Transient receptor potential non-selective cation channels
- Membrane potential
- Calcium sensitization
- Myosin light chain phosphatase
- Intracellular calcium concentration
Research Activities
Research projects conducted in my laboratory are focused on understanding the regulation of resistances arterial diameter. Our focus has been to determination of the roles, regulation, properties and molecular basis of potassum and non-selective cation channels in vascular smooth muscle cells; specifically, voltage-gated and ATP-sensitive potassium channels, and transient-receptor potential non-selective cation channel types. More recently our interests have expanded to include an examination of the role in the myogenic response of resistance arteries to transmural pressure of myofilament calcium sensitization resulting from phosphorylation of the targeting subunit of myosin phosphatase.
Administrative Assistant
Theresea Connolly
403-220-3018
tconnoll@ucalgary.ca