Publications

Click here for to see all publications on PubMed

Recent publications:

  • Acosta N, Lee J, Bautista MA, Bhatnagar S, Li C, Waddell BJ, et al. (2025) Metagenomic analysis after selective culture enrichment of hospital and community wastewater enhances antimicrobial resistance gene detection. mBio 16:e01672-25.
  • Acosta N, Beaudet AB, Westlund P, Frankowski K, Hu J, Sedaghat N, Pradhan P, Man L, Hollman J, Bautista MA, Waddell BJ, McCalder J, Penney M, Chen J, Meddings J, Achari G, Ryan MC, Cabaj JL, Clark RG, Hubert CRJ, Parkins MD (2025). Performance and suitability of wastewater based-surveillance for SARS-CoV-2 RNA in public schools. Scientific Reports 15:34364.
  • Conforti S, Pruden A, Acosta N, et al. (2025) Strengthening Policy Relevance of Wastewater-Based Surveillance for Antimicrobial Resistance. Environmental Science & Technology 59:2339-2343.
  • Lee J, Xiang K, Au E, Sarabi S, Acosta N, et al. (2025) Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods. Communications Medicine 5:7.
  • McCalder J, Lee J, Qiu J, Li Q, Immaraj L, Acosta N, et al. (2025) Consistent trends from different methods for monitoring SARS-CoV-2 in urban wastewater during a 29-month longitudinal study. Frontiers in Microbiology Volume 16 - 2025.
  • Dai, X., Acosta N., et al. (2024) A Bayesian framework for modeling COVID-19 case numbers through longitudinal monitoring of SARS-CoV-2 RNA in wastewater. Stat Med
  • Somayaji, R., Thornton, Christina S., Acosta N., et al. (2024) Evaluating Sinus Microbiology by Transplant Status in Persons With Cystic Fibrosis: A Matched Cohort Study. OTO Open 8, e101.
  • Acosta, N., et al. (2023) Wastewater-based surveillance can be used to model COVID-19-associated workforce absenteeism. Science of The Total Environment 900, 165172.
  • Parkins, M.D., Lee, B.E., Acosta, N., et al. (2023) Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond. Clinical Microbiology Reviews 0, e00103-00122.
  • Schmidt, P.J., Acosta N., et al. (2023). Realizing the value in “non-standard” parts of the qPCR standard curve by integrating fundamentals of quantitative microbiology. Frontiers in Microbiology, 14.
  • Lee, J., Acosta N., et al. (2023) Campus node-based wastewater surveillance enables COVID-19 case localization and confirms lower SARS-CoV-2 burden relative to the surrounding community. Water Research 244, 120469 (2023).
  • Svishchuk J, Ebbert K, Waddell B, Izydorczyk C, Acosta N, Somayaji R, Rabin HR, Bjornson CL, Lisboa L, Gregson DB, Conly JM, Surette MG, Parkins MD. (2023) Epidemiology and impact of methicillin-sensitive Staphylococcus aureus with β-lactam antibiotic inoculum effects in adults with cystic fibrosis. Antimicrob Agents Chemother 14;67(12):e0013623.
  • Yu, L., Acosta, N., Bautista, M.A.; McCalder, J.; Himann, J.; Pogosian, S.; Hubert, C.R.J.; Parkins, M.D.; Achari, G (2023) Quantitative Evaluation of Municipal Wastewater Disinfection by 280 nm UVC LED. Water 2023, 15, 1257.
  • Acosta N, Bautista MA, Waddell BJ, et al. (2023) Surveillance for SARS-CoV-2 and its variants in wastewater of tertiary care hospitals correlates with increasing case burden and outbreaks. Journal of Medical Virology; 95(2): e28442.
  • Saber, M.M., Donner2, J., Levade​, I., Acosta, N., et al. (2023) Single nucleotide variants in Pseudomonas aeruginosa populations from sputum correlate with baseline lung function and predict disease progression in individuals with cystic fibrosis. Microbial Genomics 9(2023).
  • Acosta, N., Bautista, MA, Waddell, BJ, et al. 2022. Longitudinal SARS-CoV-2 RNA wastewater monitoring across a range of scales correlates with total and regional COVID-19 burden in a well-defined urban population. Water Research; 220: 118611.
  • Hubert C, Acosta N, Waddell B, Hasing ME, Qiu Y, Fuzzen M, et al. 2022. Tracking Emergence and Spread of SARS-CoV-2 Omicron Variant in Large and Small Communities by Wastewater Monitoring in Alberta, Canada. Emerg Infect Dis,28(9):1770-1776.
  • Thornton, CS, Acosta, N, Surette, MG, Parkins, MD. 2022. Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation. J Pediatric Infect Dis Soc. Sep 7;11 (Supplement_2): S13-S22.
  • Nicole Acosta, María A. Bautista, Jordan Hollman, Janine McCalder, Alexander Buchner Beaudet, Lawrence Man, Barbara J. Waddell, Jianwei Chen, Carmen Li, Darina Kuzma, Srijak Bhatnagar, Jenine Leal, Jon Meddings, Jia Hu, Jason L. Cabaj, Norma J. Ruecker, Christopher Naugler, Dylan R. Pillai, Gopal Achari, M. Cathryn Ryan, John M. Conly, Kevin Frankowski, Casey RJ Hubert, Michael D. Parkins. 2021. A multicenter study investigating SARS-CoV-2 in tertiary-care hospital wastewater. viral burden correlates with increasing hospitalized cases as well as hospital-associated transmissions and outbreaks. Water Research 201:117369.
  • Acosta N, Thornton CS, Surette MG, Somayaji R, Rossi L, Rabin HR, Parkins MD. 2021. Azithromycin and the microbiota of cystic fibrosis sputum. BMC Microbiol.
  • Izydorczyk C, Waddell B, Edwards BD, Greysson-Wong J, Surette MG, Somayaji R, Rabin HR, Conly JM, Church DL, Parkins MD. 2020. Epidemiology of E. coli in Cystic Fibrosis Airways Demonstrates the Capacity for Persistent Infection but Not Patient-Patient Transmission. Front Microbiol.
  • Heirali A, Thornton C, Acosta N, Somayaji R, Laforest Lapointe I, Storey D, Rabin H, Waddell B, Rossi L, Arrieta MC, Surette M, Parkins MD. 2020. Sputum microbiota in adults with CF associates with response to inhaled tobramycin. Thorax.
  • Acosta N, Waddell B, Heirali A, Somayaji R, Surette MG, Workentine ML, Rabin HR, Parkins MD. 2020. Cystic Fibrosis Patients Infected With Epidemic Pseudomonas aeruginosa Strains Have Unique Microbial Communities.Front Cell Infect Microbiol.
  • Parkins MD, Ramos KJ, Goss CH, Somayaji R. Cytomegalovirus: an unrecognised potential contributor to cystic fibrosis disease progression? 2019 Eur Respir J
  • Whelan FJ, Waddell B, Syed SA, Shekarriz S, Rabin HR, Parkins MD, Surette MG. 2020. Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota. Nature Microbiology.
  • Edwards BD, Somayaji R, Greysson-Wong J, Izydorczyk C, Waddell B, Storey DG, Rabin HR, Surette MG, Parkins MD. 2019. Clinical Outcomes Associated with Escherichia coli Infections in Adults With Cystic Fibrosis: A Cohort Study. Open Forum Infect Dis.
  • Lam JC, Gregson DB, Robinson S, Somayaji R, Conly JM, Parkins MD. 2019.Epidemiology and Outcome Determinants of Staphylococcus aureus Bacteremia Revisited: A Population-Based Study. Infection.
  • Woo TE, Lim R, Heirali AA, Acosta N, Rabin HR, Mody CH, Somayaji R, Surette MG, Sibley CD, Storey DG, Parkins MD. 2019. A longitudinal characterization of the Non-Cystic Fibrosis Bronchiectasis airway microbiome. Sci Rep.
  • Parkins MD, Ramos KJ, Goss CH, Somayaji R. 2019. Cytomegalovirus: an unrecognised potential contributor to cystic fibrosis disease progression?. Eur Respir J.
  • Heirali AA, Acosta N, Storey DG, Workentine ML, Somayaji R, Laforest-Lapointe I, Leung W, Quon BS, Berthiaume Y, Rabin HR, Waddell BJ, Rossi L, Surette MG, Parkins MD. 2019. The effects of cycled inhaled aztreonam on the cystic fibrosis (CF) lung microbiome. J Cyst Fibros.
  • Parkins MD, Somayaji R, Waters VJ. 2018. Epidemiology, Biology, and Impact of Clonal Pseudomonas aeruginosa Infections in Cystic Fibrosis. Clin Microbiol Rev.
  • Acosta N, Heirali A, Somayaji R, Surette MG, Workentine ML, Sibley CD, Rabin HR, Parkins MD. 2018. Sputum microbiota is predictive of long-term clinical outcomes in young adults with cystic fibrosis. Thorax.
  • Acosta N, Whelan, FJ, Somayaji, R, Poonja, A, Surette, MG, Rabin, HR, and Parkins, MD. 2017. The evolving Cystic Fibrosis microbiome: A comparative cohort study spanning sixteen years. Annals of the American Thoracic Society.
  • Heirali AA, Workentine ML, Acosta N, Poonja A, Storey DG, Somayaji R, Rabin, HR, Whelan, FJ, Surette, MG., and Parkins, MD. 2017. The effects of inhaled aztreonam on the cystic fibrosis lung microbiome. Microbiome.
  • Heirali A, McKeon S, Purighalla S, Storey DG, Rossi L, Costilhes G, Drews SJ, Rabin HR, Surette MG, Parkins MD. 2016. Assessment of the Microbial Constituents of the Home Environment of Individuals with Cystic Fibrosis (CF) and Their Association with Lower Airways Infections. PLoS One.
  • Poonja A, Heirali A, Workentine M, Storey DG, Somayaji R, Rabin HR, Surette MG, Parkins MD. 2017. Effect of freezing sputum on Pseudomonas aeruginosa population heterogeneity. J Cyst Fibros.
  • Syed, SA, Whelan, FJ, Waddell B, Rabin, HR, Parkins, MD and MG. Surette.  2016.  Re-emergence of Recipient Microbiota in Cystic Fibrosis Lung Transplant Patients. Annals of American Thoracic Society.