Research Publications

Marszalek, J., De Los Rios. P., Cyr, D., Mayer, M.P., Adupa, V., Andréasson, C., Blatch, G.L., Braun, J.E.A., Brodsky, J.L., Bukau, B., Chapple, J.P., Conz, C., Dementin, S., Genevaux, P., Genest, O., Goloubinoff, P., Gestwicki, J., Hammond, C.M., Hines, J.K., Ishikawa, K., Joachimiak, L.A., Kirstein, J., Liberek, K., Mokranjac. D., Nillegoda, N., Ramos, C.H.I., Rebeaud, M., Ron, D., Rospert, S., Sahi, C., Shalgi, R., Tomiczek, B., Ushioda, R., Ustyantseva, E., Ye, Y., Zylicz, M., Kampinga, H.H. (2023) J-domain Proteins: From Molecular Mechanisms to Diseases. Cell Stress Chaperones. PubMed. 2023 Dec 23;29(1):21-33.

Braun, J.E.A. (2023) Extracellular Chaperone Networks and the Export of J-domain Proteins. Journal Of Biological Chemistry. Volume 299, Issue 2

Pink, D., Donnelier, J., Lewis, J.D. and Braun, J.E.A. (2022) Cysteine String Protein Controls Two Routes of Export for Misfolded Huntingtin. Front. Neurosci. 15:762439. 

Roodveldt, C., Outeiro, T.F. and Braun, J.E.A., (2017) Editorial: Molecular Chaperones and Neurodegeneration. Front Neurosci. 2017 Oct 11;11:565.

Deng, J., Koutras, C., Donnelier, J., Alshehri, M., Fotouhi, M., Girard, M., Casha, S., McPherson, P.S., Robbins, S.M. and Braun, J.E.A. (2017) Neurons Export Extracellular Vesicles Enriched in Cysteine String Protein and Misfolded Protein Cargo.  Nature. Scientific Reports 7, Article number: 956 .

Donnelier, J. Braun, S.T., Dolzhanskaya, N., Ahrendt, E., Braun, A.P., Velinov, M. and Braun, J.E.A. (2015) Increased Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel in Adult-Onset Neuronal Ceroid Lipofuscinosis. PLoS ONE 10(4): e0125205.

Koutras, C. and Braun, J.E.A., (2014) J protein mutations and resulting proteostasis collapse. Front. Cell. Neuroscience 10:3389 (00191) .

Donnelier, J. and Braun, J.E.A. (2014) CSP?-chaperoning presynaptic proteins. Front Cell Neurosci. Apr 29;8:116. eCollection 2014. Front Cell Neuroscience 8:3389 (00116).   

Ahrendt, E., Kyle, B.D., Braun, A.P. and Braun, J.E.A. (2014) Cysteine String Protein Limits Expression of the Large Conductance, Calcium-activated K(+) (BK) Channel. PLoS One 10.1371 :e86586.

Kyle, B.D., Ahrendt, E., Braun, A.P. and Braun, J.E.A. (2013) The Large Conductance, Calcium-activated K(+) (BK) Channel is regulated by Cysteine String Protein. Sci Rep.  08:3:2447

Carnini, A., Scott, L.O., Ahrendt, E., Proft, J., Winkfein, R.J., Kim, S.W., Colicos, M.A. and Braun, J.E.A. (2012) Cell line specific modulation of extracellular A?42 by Hsp40. PLoS One. 7(5):e37755.

Elwi, A.N., Lee, B., Meijndert, H.C., Braun, J.E.A. and Kim S.W. (2012) Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation. Int J Biochem Cell Biol. Aug;44(8):1366-76 .

Proft, J., Faraji, J., Robbins, J.C., Zucchi, F.C., Zhao, X., Metz, G.A. and Braun, J.E.A.  (2011) Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease. PLoS One. 6(10):e26045.

Ahrendt, E. and Braun, J.E.A. (2010) Channel triage: Emerging insights into the processing and quality control of hERG potassium channels by DnaJA proteins 1, 2 and 4.  Channels (Austin). Sep-Oct;4(5):335-6.

Xu, F., Proft, J., Gibbs, S., Winkfein, B., Johnson, J.N., Syed, N. and Braun, J.E.A. (2010) Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission. PloS One 5(6):e 11045

Johnson, J.N., Ahrendt, E. and Braun, J.E.A. (2010) CSP?: the neuroprotective J protein. Biochemistry and Cell Biology 88(2) 157-165

Carnini, A.,  Casha, S., Yong, V.W., Hurlbert, R.J. and Braun, J.E.A.  (2010) Reduction of PrPC in human cerebrospinal fluid after spinal cord injury.  Prion 4(2).

Weng, N., Baumler, M., Thomas, D.D.H., Swayne, L.A., Braun, J.E.A. and Groblewski, G.E.(2009) Funtional Role of Cysteine String Protein's J Domain in Ca2+-Dependent Secretion from Acinar Cells. Am J. Phys. 265 (5) :G1030-1039 .

Gibbs, S., Barren, B., Beck, K.E., Proft, J., Zhao, X., Noskova, T., A., Braun, A.P., Artemyev, N.O. and Braun, J.E.A. (2009) Hsp40 Transiently Assembles with the CSP? Chaperon Complex upon induction of the heat shock response. PLOS ONE 4(2):E4595

Rosales-Hernandez, A., Beck, K.E., Zhao, X., Braun, A.P. and Braun, J.E.A. (2009) Rdj2 (DnaJA2) Chaperones Neural G Protein Signalling Pathways. Cell Stress & Chaperones.14:71-82

Gibbs, S.J. and Braun, J.E.A. (2008) Emerging Roles of J Proteins in Neurodegenerative Disorders. Neurobiology of Disease 32 196-199.

Zhao, X., Braun, A.P. and Braun, J.E.A. (2008) Biological Roles of Neural J proteins. Cellular and Molecular Life Sciences Aug;65(15):2385-96.

Sheng, J.-Z., Arshad, F., Braun, J.E.A. and Braun, A. (2008) Estrogen and the Ca-mobilizing Agonist ATP Evoke Acute Nitric Oxide Synthesis via Distinct Pathways in an Individual Human Vascular Endothelial Cell.  American Journal of Physiology Vol. 294no. C1531-C1541.

Swayne, L.A. and Braun, J.E.A. (2007) Aggregate-centered redistribution of proteins by mutant huntingtin. Biochemical Biophysical Research Communications. 354: 39-44.

Bai, L., Swayne, L.A. and Braun, J.E.A. (2007) The CSP?/G protein complex in PC12 cells. Biochemical Biophysical Research Communications. 352(1): 123-129.

Beck, K.E., Kay, J.G. and Braun, J.E.A. (2006) Rdj2, a J protein family member, interacts with cellular prion PrP^c . Biochemical Biophysical Research Communications 346(3) 866-871.

Swayne, L.A., Beck, K.E. and Braun, J.E.A. (2006) The Cysteine String Protein Multimeric Complex. Biochemical Biophysical Research Communications. 348: 83-91.

Natochin, M., Campbell, T.N., Barren, B., Miller, L.C., Hameed, S., Artemyev, N.O. and Braun, J.E.A. (2005) Characterization of the G ?lpha(s) regulator cysteine string protein. J. Biol. Chem. 280 (34) 30236-30241.

Swayne, L.A., Chen, L., Hameed, S., Barr, W., Charlesworth, E., Colicos, M.A., Zamponi, G.W. and Braun, J.E.A. (2005) Crosstalk between huntingtin and syntaxin regulates presynaptic calcium channels. Molecular and Cellular Neuroscience. 30: 339-351
 

Sayani, F.A., Keenan, C.M., Van Sickle, M.D., Amundson, K.R., Parr, E.J., Mathison, R.D., MacNaughton, W.K.., Braun, J.E.A. and Sharkey, K.A. (2004) The Expression and Role of Fas Ligand in Intestinal Inflammation. Neurogastroenterology and Motility. 16 61-74.

Selak, S., Braun, J.E.A. and Fritzler, M.J. (2004). Characterization of Early Endosome Antigen 1 (EEA1) in Neural Tissue. Biochemical Biophysical Research Communications 323 1334-1342.

Miller, L.C., Swayne, L.A., Chen, L., Feng, Z.P., Wacker, J.L., Muchowski, P.J., Zamponi, G.W. and Braun, J.E.A. (2003) CSP Inhibition of N-type Calcium channels is Blocked by Mutant Huntingtin. J. Biol. Chem. 278 53072-53081.

Szule, J.A., Jarvis, S.E., Hibbert, J.E., Spafford, J.D., Braun, J.E.A., Zamponi, G.W., Wessel, G. and Coorssen, J.R. (2003). Specific presynaptic proteins function upstream of triggered membrane fusion. J. Biol. Chem. 278 24251-24254.

Ling, S., Sheng, J.Z., Braun, J.E.A. and Braun, A.P. (2003) Syntaxin 1A co-associates with native rat brain and cloned large conductance, calcium-activated K+ channels in situ. Journal of Physiology (Lond.). 533.1 65-81. [A picture from our paper graces the cover of this issue of the journal].

Miller, L.C., Swayne, L., Kay, J.G., Feng, Z.-P., Jarvis, S.E., Zamponi, G.W. and Braun, J.E.A. (2003) Molecular determinants of cysteine string protein modulation of N-type calcium channels. Journal of Cell Science. 116 2967-2974.

Swayne, L.A., Blattler, C., Kay, J.G. and Braun, J.E.A. (2003) Oligomerization Characteristics of Cysteine String Protein. Biochemical Biophysical Research Communications. 300 921-926.

Magga, J.M., Kay, J.G., Davy, A., Poulton, N.P., Robbins, S.M. and Braun, J.E.A. (2002) ATP dependence of the SNARE/caveolin1 interaction in the hippocampus. Biochemical Biophysical Research Communications. 291(5) 1232-1238.

Magga, J.M., Jarvis, S.E., Arnot, M.I., Zamponi, G.W. and Braun, J.E.A. (2000) Cysteine string protein regulates G-protein-modulation of N-type calcium channels. Neuron 28, 195-204.

Fisher, H. and Braun, J.E.A. (2000) Modulation of the SNARE core complex by dopamine. The Canadian Journal of Physiology and Pharmacology. 78 (20) 856-859.

Braun, J.E.A. and Madison, D.V. (2000) A novel SNAP25-caveolin complex correlates with the onset of persistent synaptic potentiation. J. Neuroscience. 20 5997-6006.

Jarvis, S.E., Magga, J.M., Beedle, A.M., Braun, J. E. A. and Zamponi, G.W. (2000). G-protein modulation of N-type calcium channels is facilitated by physical interactions between syntaxin 1A and G??. J. Biol. Chem. 275 6388-6394.

Brown, H., Larsson, O., Branstrom, R., Yang, S., Leibiger, B., Leibiger, I., Fried, G., Moede, T., Deeney, J.T., Brown, G.R, Jacobsson, G., Rhodes, C.J., Braun, J.E.A., Scheller, R.H., Corkey, B.E., Berggren, P. and Meister, B. (1998) Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating ?-cell exocytosis. The EMBO Journal. 17 5048-5058.

Braun, J.E.A., Wilbanks, S.M. and Scheller, R.H. (1996) The cysteine string secretory vesicle protein activates Hsc70 ATPase. J. Biol. Chem. 271 25989-25993.

Braun, J.E.A. and Scheller, R.H. (1995) Cysteine string protein, a Dna J family member, is present on diverse secretory vesicles. Neuropharmacology 34 1361-1369.

Pevsner, J., Hsu, S-C., Braun, J.E.A., Calakos, N., Ting, A.E., Bennett, M.K. and Scheller, R.H. (1994) Specificity and regulation of a synaptic vesicle docking complex. Neuron 13 353-361. [A key paper in the field with >430 citations]

Braun, J.E.A., Fritz, B., Wong, S.M.E. and Lowe, A.W. (1993) Identification of a VAMP-like membrane protein in zymogen granules of the rat exocrine pancreas. J. Biol. Chem. 269 5328-5335.

Braun, J.E.A. and Severson, D.L. (1992) Tissue-specific regulation of lipoprotein lipase. Can. Med. Ass. J. 147 (8) 1192.

Braun, J.E.A. and Severson D.L. (1992) Review Article: Regulation of the synthesis, processing and translocation of lipoprotein lipase. Biochem. J. 287 337-347.

Rodrigues, B., Braun J.E.A., Spooner, M., and Severson, D.L. (1992) Regulation of lipoprotein lipase activity in control and diabetic rat hearts by plasma lipids. Can. J. Physiol. Pharm. 70 1271-1279.

Braun, J.E.A. and Severson, D.L. (1992) Release of lipoprotein lipase activity in control and diabetic rat hearts by low molecular weight heparin. Lipids 28(1) 59-61.

Braun, J.E.A. and Severson, D.L. (1992) The secretion/release of lipoprotein lipase from cardiac myocyte suspensions is altered by vanadium but not insulin. Am. J. Physiol. 262 E663-E670.

Braun, J.E.A. and Severson, D.L. (1991) Diabetes reduces the heparin-and phospholipase C-releasable lipoprotein lipase from cardiomyocytes. Am. J. Physiol. 260 E477-E485.

Sulakhe, P.V., MacKay, J.E.A., Rokosh, D.G., Morris, T.E. and Phan, T.D. Parasympathetic control of the heart. In Subcellular Mechanisms in Heart Function & Metabolism (N.S. Dhalla, G.N. Pierce, R.E., Beamish, eds) Martinus Nijhoff