EAE

Publications

Peer reviewed papers (lab members bolded, #corresponding author)

 

Hagen KM, Gordon P, Frederick A, Palmer AL, Edalat P, Zonta YR, Scott L, Flancia F, Reid JK, Joel M, and Ousman SS# (2023) CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system. Neurobiol Aging 133:1-15.

 

Umansky D, Hagen KM, Chu TH, Pathiyil RK, Alzahrani S, Ousman SS and Midha R (2022) Functional Gait Assessment Using Manual, Semi-automated and Deep Learning Approaches Following Standardized Models of Peripheral Nerve Injury in Mice. Biomolecules 12(10):1355.

 

Hagen KM and Ousman SS# (2021) Aging and the Immune Response in Diabetic Peripheral Neuropathy. Journal of Neuroimmunology 355(577574): 1-13. (review)

 

Lim EM, Hoghooghi V, Hagen KM, Kapoor K, Frederick A, Finlay TM and Ousman SS# (2021) Presence and activation of pro-inflammatory macrophages is associated with CRYAB expression in vitro and after peripheral nerve injury. Journal of Neuroinflammation 18(82): 1-16.

 

Hagen KM and Ousman SS# (2021) The Immune Response and Aging in Chronic Inflammatory Demyelinating Polyradiculoneuropathy. Journal of Neuroinflammation 18(78): 1-18. (review)

 

Hagen KM and Ousman SS# (2021) The Neuroimmunology of Guillain-Barré Syndrome and the Potential Role of an Aging Immune System. Frontiers in Aging Neuroscience 12(613628): 1-19. (review)

 

Hoghooghi V, Palmer AL, Frederick A, Jiang Y, Merkens JE, Balakrishnan A, Finlay TM, Grubb A,Levy E, Gordon P, Jirik FR, Nguyen MD,Schuurmans C, Visser F, Dunn SE and Ousman SS# (2020) Cystatin C Plays a Sex-Dependent Detrimental Role in Experimental Autoimmune Encephalomyelitis. Cell Reports 33(108236): 1-24.

 

Palmer AL and Ousman SS# (2018) Astrocytes and Aging. Frontiers in Aging Neuroscience 10(337): 1-14. (review)

 

Rothbard JB, Kurnellas MP, Ousman SS, Brownell S, Rothbard JJand Lawrence SteinmanL (2018) Small Heat Shock Proteins, Amyloid Fibrils and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications For Future Therapies. Cold Spring Harbor Perspectives in Medicine 9(a034223): 1-15.

 

Caprariello AV, Rogers JA, Morgan ML, Hoghooghi V, Plemel JR, Koebel A, Tsutsui S, Dunn JF, Kotra LP, Ousman SS, Yong VW and Stys PK (2018) Biochemically-altered myelin triggers autoimmune demyelination. Proceedings of the National Academy of Sciences USA 115(21):5528-5533.

 

Finlay TM, Palmer AL and Ousman SS# (2018) Murine neutrophils treated with alphaB-crystallin reduce IL-12p40 production by dendritic cells. Immunology 155: 72-84.

 

Ousman SS#, Frederick A and Lim EMF (2017) Chaperone proteins in the central nervous system and peripheral nervous system after nerve injury. Frontiers in Neuroscience 11(79): 1-10. (Invited review)

 

Lim EMF, Musa A, Frederick A and Ousman SS#(2017) AlphaB-crystallin expression correlates with aging deficits in the peripheral nervous system. Neurobiology of Aging 53: 138-149.

 

Lim EMF, Nakanishi ST, Hoghooghi V, Eaton SEA, Palmer AL, Frederick A, Stratton JA, Stykel MG, Whelan PJ, Zochodne DM,Biernaskie J and Ousman SS# (2017) AlphaB-crystallin regulates remyelination following peripheral nerve injury. Proceedings of the National Academy of Sciences USA 114(9): E1707-E1716.

 

Scott BNV, Roberts DJ, Robertson HL, Kramer AH, Lauplan KB, Ousman SS, Kubes P and Zygun D (2013) Incidence, prevalence, and occurrence rate of infection among adults hospitalized after traumatic brain injury: study protocol for a systematic review and meta-analysis. Systematic Reviews 2(68): 66-74.

 

AcharjeeS, NayaniN, TsutsuiM, HillMN, Ousman SSand Pittman QJ (2013)Altered cognitive-emotional behavior in early experimental autoimmune encephalitis - cytokine and hormonal correlates. Brain Behavior and Immunity 33: 164-72.

 

Quach QL, Metz LM, Thomas JC, Rothbard JB, Steinman L and OusmanSS# (2013) CRYAB modulates the activation of CD4+ T cells from relapsing-remitting multiple sclerosis patients. Multiple Sclerosis Journal 19(14):1867-1877. 

 

Oyebamiji AI, Finlay TM, Hough RM, Hoghooghi V, Lim EM, Wong CHY and Ousman SS# (2013) Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB. Journal of Neuroimmunology 259(1-2):66-74.

 

Steinman L, Axtell RC, Barbieri D, Bhat R, Brownell SE, de Jong BA, Dunn SE, Grant JL, Han MH, Ho PP, Kuipers HF, Kurnellas MP, Ousman SS and Rothbard JB (2013) Piet Mondrian's trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011. Multiple Sclerosis Journal 19(1):5-14.

 

Kurnellas MP, Brownell S, Su L, Leon S, Malkovskiy AV, Rajadas J, Dolganov G, Chopra S, SchoolnikGK, Sobel RA, Webster J, Ousman SS, Becker RA, Steinman L and Rothbard JB (2012) Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis. Journal of Biological Chemistry 287(43):36423-34.

 

Ousman SS# andKubes P# (2012) Immune surveillance in the central nervous system. Nature Neuroscience 15(8):1096-1101. (Invited review)

 

Pangratz-Fuehrer S, Kaur K, Ousman SS, Steinman L and Liao YP (2011). Functional rescue of experimental ischemic optic neuropathy with B-crystallin. Eye 25(6): 809-817.

 

deLucaLS, Pikor N, O’Leary N, Galicia-RosasG, Ward LA, Defreitas D, Finlay TM, Ousman SS, Osborne LR and GommermanJL (2010) Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis. Journal of Immunology 184(6):3174-85.

 

Hung J, Chansard M, Ousman SS, Nguyen MD and Colicos MA (2010) Activation of microglia by neuronal activity: results from a new in vitro paradigm based on neuronal-silicon interfacing technology. Brain Behavior Immunity 24(1):31-40.

 

Han MH, Hwang S-I, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK and Steinman L (2008) Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 451 (7182):1076-81.

 

Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O’Conner K, Hafler DA, Sobel RA, Robinson WH and Steinman L (2007)Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature 448 (7152): 474-479.

 

Dunn SE*, Ousman SS*, Sobel R, Zuniga L, Crowell A, Loh J and Steinman L (2007) Peroxisome proliferator-activated receptor (PPAR)-alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. Journal of Experimental Medicine 204(2): 321-330. *Co-first authors

 

Wacher C, Müller M, Markus HJ, Getts DR, Zabaras R, Ousman SS, Terenzi F, Sen GC, King NJC and Campbell IL (2006) Coordinated regulation and widespread cellular expression of the interferon stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system after infection with distinct viruses. Journal of Virology 81(2):860-71. 

 

Ousman SS, Wang JP and Campbell IL (2005) Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during LCMV viral infection. Journal of Virology 79(12):7514-27.

 

Ousman SS and Campbell IL (2005) Regulation of murine interferon regulatory factor gene expression in the central nervous system determined by multiprobe RNase protection assay. In: Methods in Molecular Medicine: Interferon Methods and Protocols, Humana Press Inc., Totowa, NJ. Ed. Carr, Daniel J. J. Vol. 116 p. 115-134. (Invited book chapter)

 

David S and Ousman SS (2002) Recruiting the immune response to promote axon regeneration in the injured spinal cord. The Neuroscientist 8(1): 33-41. (Invited review)

 

David S and Ousman S (2002) Stimulating immune system – central nervous system interaction to promote long distance axon regeneration.  In: Glial Interfaces in the Nervous System, Hakan Aldskogius and John Frahar (eds), IOS Press, Amsterdam, Netherlands, 2002, pp 153-164. (Invited book chapter)

 

Ousman SS and David S (2001) MIP-1alpha, MCP-1, GM-CSF, and TNF control the immune response mediates rapid phagocytosis of myelin from the adult mouse spinal cord. Journal of Neuroscience 21(13):4649-4656.

 

Ousman SS and David S (2000) Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord. GLIA 30 (1): 92-104.

 

Issued patents

 

Steinman L, Ousman SS and Robinson WH. Alpha B-crystallin as a therapy for multiple sclerosis. Stanford University Office of Technology Transfer, Stanford, CA, USA. US Patent No. 8,835,391; filed May 29, 2000, Issued September 16, 2014.

 

Steinman L, Ousman SS and Robinson WH. Alpha B-crystallin as a therapy for ischemia or inflammation. Stanford University Office of Technology Transfer, Stanford, CA, USA. US Patent No. 8,771,689; filed June 23, 2011, Issued July 8, 2014.

 

Steinman L, Ousman SS and Robinson WH. Alpha B-crystallin as a therapy for autoimmune demyelination. Stanford University Office of Technology Transfer, Stanford, CA, USA. Israeli Patent No. 199223; Issued April 30, 2013.

 

Steinman L, Ousman SS and Robinson WH. AlphaB-crystallin as a therapy for rheumatoid arthritis. Stanford University Office of Technology Transfer, Stanford, CA, USA. US Patent No. 7,875,589; filed December 11, 2007, Issued January 25, 2011, Licensed to Cardinal Therapeutics.