Publications

All publications in MyNCBI

Selected publications

  1. Sun J, Belke D, Gui Y, Chen YX, Zhou S, Zheng XL. Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis. Cell Death Discov. 2023; 9(1):49. 
  2. Tai S, Sun J, Zhou Y, Zhu Z, He Y, Chen M, Yang H, Xiao Y, Tu T, Tang L, Li X, Zeng J, Zheng X, Zhou S. Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux. J Adv Res. 2022; 41:205-218.
  3. Guo Y, Tang Z, Yan BJ, Yin H, Tai S, Peng J, Cui Y, Gui Y, Belke D, Zhou S, Zheng XL. PCSK9 (proprotein convertase subtilisin/kexin type 9) triggers vascular smooth muscle cell senescence and apoptosis: implication of its direct role in degenerative vascular disease. Arterioscler Thromb Vasc Biol. 2022, 42(1): 67-86.
  4. Zhou L, Liu J, Bu LL, Liao DF, Cheng SW, Zheng XL. Curcumin Acetylsalicylate Extends the Lifespan of Caenorhabditis elegans. Molecules 2021, 26, 6609.
  5. Guo Y, Yan B, Tai S, Zhou S, Zheng XL. PCSK9: Associated with cardiac diseases and their risk factors? Arch Biochem Biophys. 2021; 704: 108717.
  6. Yan B, Guo Y, Gui Y, Jiang ZS, Zheng XL. Multifunctional RNase MCPIP1 and its role in cardiovascular diseases. Curr Med Chem. 2021; 28: 3385-3405.
  7. Guo Y, Yan B, Gui Y, Tang Z, Tai S, Zhou S, Zheng XL. Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall. J Cell Physiol. 2021; 236: 2333–2351.
  8. Xia X, Zhang L, Chi J, Li H, Liu X, Hu T, Li R, Guo Y, Zhang X, Wang H, Cai J, Li Y, Liu D, Cui Y, Zheng XL, Flaker GC, Liao D, Hao H, Liu Z, Xu C. Helicobacter pylori infection impairs endothelial function through an exosome-mediated mechanism. J Am Heart Assoc. 2020; 9: 014120.
  9. Tang ZH, Li TH, Peng J, Zheng J, Li TT, Liu LS, Jiang ZS, Zheng XL. PCSK9: A novel inflammation modulator in atherosclerosis? J Cell Physiol. 2019; 234: 2345-2355.
  10. He PP, Jiang T, OuYang XP, Liang YQ, Zou JQ, Wang Y, Shen QQ, Liao L, Zheng XL. Lipoprotein lipase: Biosynthesis, regulatory factors, and its role in atherosclerosis and other diseases. Clin Chim Acta. 2018; 480:126-137.
  11. Tan X, Gao J, Shi Z, Tai S, Chan LL, Yang Y, Peng DQ, Liao DF, Jiang ZS, Chang Y, Gui Y, Zheng XL. MG132 induces expression of monocyte chemotactic protein-induced protein 1 in vascular smooth muscle cells. J Cell Physiol. 2017; 232: 122-8.
  12. Singh P, Li D, Gui Y, Zheng XL. Atrogin-1 increases smooth muscle contractility through myocardin degradation. J Cell Physiol. 2017; 232: 806-817.
  13. Zhou YX, Shi Z, Singh P, Yin H, Yu YN, Li L, Walsh MP, Gui Y, Zheng XL. Potential role of glycogen synthase kinase-3β in regulation of myocardin activity in human vascular smooth muscle cells. J Cell Physiol. 2016; 231: 393-402.
  14. Zheng XL. Myocardin and smooth muscle differentiation. Arch Biochem Biophys. 2014; 543: 48–56.
  15. Singh P and Zheng XL. Dual Regulation of myocardin expression by tumor necrosis factor-α in vascular smooth muscle cells. PLoS ONE. 2014; 9: e112120.
  16. Jiang Y, Singh P, Yin H, Zhou YX, Gui Y, Wang DZ, Zheng XL. Opposite roles of myocardin and atrogin-1 in L6 myoblast differentiation. J Cell Physiol. 2013; 228: 1989-95.           
  17. Yuan W, Yu Y, Li J.J., Singh P, Li D, Gui Y, Zheng XL. Estrogen metabolite 2-methoxyestradiol prevents hypertension in deoxycorticosterone acetate-salt rats. Cardiovasc Drugs Ther. 2013; 27: 17-22.
  18. Yuan W, Wang ZY, Li J.J., Li D, Liu DL, Bai G, Walsh MP, Gui Y, Zheng XL. Uridine adenosine tetraphosphate induces contraction of circular and longitudinal gastric smooth muscles by distinct signaling pathways. IUBMB Life. 2013; 65: 623-32.
  19. Tian R, Wang ZY, Shi Z, Li D, Wang Y, Zhu R, Lin W, Gui Y, Zheng XL. Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. Fertil Steril. 2013; 99: 256-263.
  20. Li H, Li J.J., Li Y, Singh P, Cao L, Xu L, Li D, Wang Y, Xie Z, Gui Y, Zheng XL. Sonic hedgehog promotes autophagy of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2012; 303: H1319–H1331.
  21. Li J, Jiang J, Yin H, Wang L, Tian R, Li H, Li D, Wang Y, Gui Y, Walsh MP, Zheng XL. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. Hypertension. 2012; 60: 145-153.
  22. Gao G, Li J, Li Y.N., Wang YB, Li D, Walsh MP, Gui Y, Zheng XL. Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility. Am J Physiol Heart Circ Physiol. 2011; 300: H1583-94.
  23. Gui Y, Wang ZY, Sun X, Walsh MP, Li J.J., Gao J, Zheng XL. Uridine adenosine tetraphosphate induces contraction of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2011; 301: L789-94.
  24. Ren YY, Yin H, Tian R, Cui L, Zhu Y, Lin W, Tang X, Gui Y, Zheng XL. Differential effects of epidermal growth factor on smooth muscle cells derived from human myometrium and leiomyoma. Fertil Steril. 2011; 96: 1015-20.
  25. Gui Y, Walsh MP, He G, Zheng XL. Signaling mechanisms mediating Up4A-induced proliferation of human smooth muscle cells. J Cardiovasc Pharmacol. 2011; 58: 654-62.
  26. Chen J, Yin H, Jiang Y, Radhakrishnan SK, Huang ZP, Li J, Shi Z, Kilsdonk EP, Gui Y, Wang DZ, Zheng XL. Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. Arterioscler Thromb Vasc Biol. 2011; 31: 368-75.
  27. Cui L, Ren YY, Yin H, Wang Y, Li D, Liu M, Zhu Y, Lin W, Tang XD, Gui Y, Zheng XL. Increased expression of tuberin in human uterine leiomyoma. Fertil Steril. 2011; 95: 1805-8.
  28. Yin H, Jiang Y, Li H, Li J, Gui Y, Zheng XL. Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells. J Cell Physiol. 2011; 226: 1897-906.
  29. Jiang Y, Yin H, Zheng XL. MicroRNA-1 inhibits myocardin-induced contractility of human vascular smooth muscle cells. J Cell Physiol. 2010; 225: 506-11.
  30. Yin H, Gui Y, Du G, Frohman MA, Zheng XL. Dependence of phospholipase d1 multi-monoubiquitination on its enzymatic activity and palmitoylation. J Biol Chem. 2010; 285: 13580-8.
  31. Yin H, Gui Y, Zheng XL. 2-methoxyestradiol inhibits atorvastatin-induced rounding of human vascular smooth muscle cells. J Cell Physiol. 2010; 222: 556-64.
  32. Gui Y, Zheng XL, Zheng J, Walsh MP. Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol. Am J Physiol Heart Circ Physiol. 2008; 295: H1935-42.
  33. Gui Y, Walsh MP, Jankowski V, Jankowski J, Zheng XL. Up4A stimulates endothelium-independent contraction of isolated rat pulmonary artery. Am J Physiol Lung Cell Mol Physiol. 2008; 294: L733-8.
  34. Tang R-Hx, Zheng XLx, Callis TE, Stansfield WE, He J, Baldwin AS, Wang D-Z, Selzman CH. Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression. Proc Natl Acad Sci USA. 2008; 105: 3362-7. x Equal contribution
  35. Gui Y, He G.H., Walsh MP, Zheng XL. Predisposition to tetraploidy in pulmonary vascular smooth muscle cells derived from the Eker rats. Am J Physiol Lung Cell Mol Physiol. 2007; 293: L702-11.
  36. Zheng XL, Yuan SG, Peng DQ. Phenotype-specific inhibition of the vascular smooth muscle cell cycle by high glucose treatment. Diabetologia. 2007; 50: 881-90.
  37. Gui Y, Yin H, He J.Y., Yang SH, Walsh MP, Zheng XL. Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: A role for cyclin-dependent kinase 2. Am J Physiol Heart Circ Physiol. 2007; 292: H1313-20.
  38. Zheng XL, Wong NC. Cyclosporin A inhibits apolipoprotein A.I. gene expression. J Mol Endocrinol. 2006; 37: 367-73.
  39. Gui Y, Zheng XL. 2-methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells. Hypertension. 2006; 47: 271-80.
  40. Zheng XL, Gui Y, Du G, Frohman MA, Peng DQ. Calphostin-C induction of vascular smooth muscle cell apoptosis proceeds through phospholipase D and microtubule inhibition. J Biol Chem. 2004; 279: 7112-8.
  41. Gui Y, Zheng XL. Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway. J Biol Chem. 2003; 278: 53017-25.
  42. Zheng XL, Matsubara S, Diao C, Hollenberg MD, Wong NCW. Epidermal growth factor induction of apolipoprotein A.I. is mediated by the Ras-MAP kinase cascade and Sp1. J Biol Chem. 2001; 276: 13822-9.
  43. Zheng XL, Matsubara S, Diao C, Hollenberg MD, Wong NCW. Activation of apolipoprotein A.I. gene expression by protein kinase A and kinase C through transcription factor, Sp1. J Biol Chem. 2000; 275: 31747-54.
  44. Gui Y, Zheng XL, Hollenberg MD. Interleukin-1β, Src-and non-Src tyrosine kinases, and nitric oxide synthase induction in rat aorta in vivo. Am J Physiol Heart Circ Physiol. 2000; 279: H566-76.
  45. Zheng XL, Gui Y, Sharkey KA, Hollenberg MD. Differential induction of nitric oxide synthase in rat gastric and vascular smooth muscle tissue: distinct tissue distribution and distinctive signaling pathways. J Pharmacol Exp Ther. 1999; 289: 632-40.
  46. Zheng XL, Renaux B, Hollenberg MD. Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol 3'-kinase. J Pharmacol Exp Ther. 1998; 285: 325-34.
  47. Zheng XL, Guo J, Wang HY, Malbon CC. Expression of constitutively activated Gialpha2 in vivo ameliorates streptozotocin-induced diabetes. J Biol Chem. 1998; 273: 23649-51.
  48. Zheng XL, Mokashi S, Hollenberg MD. Contractile action of ethanol in guinea pig gastric smooth muscle: inhibition by tyrosine kinase inhibitors and comparison with the contractile action of epidermal growth factor-urogastrone. J Pharmacol Exp Ther. 1997; 282: 485-95.
  49. Zheng XL, Sharkey KA, Hollenberg MD. Induction of nitric oxide synthase in rat gastric smooth muscle preparations. Am J Physiol Gastrointest Liver Physiol. 1997; 273: G1101-7.