Selected Publications

1. Muruve DA, Barnes MJ, Stillman IE, and Libermann TA. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Human gene therapy. 1999;10(6):965-76.

2. Borgland SL, Bowen GP, Wong NC, Libermann TA, and Muruve DA. Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB. Journal of virology. 2000;74(9):3941-7.

3. Tibbles LA, Spurrell JC, Bowen GP, Liu Q, Lam M, Zaiss AK, Robbins SM, Hollenberg MD, Wickham TJ, and Muruve DA. Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10. Journal of virology. 2002;76(4):1559-68.

4. Zaiss AK, Liu Q, Bowen GP, Wong NC, Bartlett JS, and Muruve DA. Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors. Journal of virology. 2002;76(9):4580-90.

5. Muruve DA, Cotter MJ, Zaiss AK, White LR, Liu Q, Chan T, Clark SA, Ross PJ, Meulenbroek RA, Maelandsmo GM, and Parks RJ. Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. Journal of virology. 2004;78(11):5966-72.

6. Petrilli V, Dostert C, Muruve DA, and Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Current opinion in immunology. 2007;19(6):615-22.

7. Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, Ross PJ, Parks RJ, and Tschopp J. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature. 2008;452(7183):103-7.

8. Ng J, Hirota SA, Gross O, Li Y, Ulke-Lemee A, Potentier MS, Schenck LP, Vilaysane A, Seamone ME, Feng H, Armstrong GD, Tschopp J, Macdonald JA, Muruve DA, and Beck PL. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology. 2010;139(2):542-52, 52.e1-3.

9. Vilaysane A, Chun J, Seamone ME, Wang W, Chin R, Hirota S, Li Y, Clark SA, Tschopp J, Trpkov K, Hemmelgarn BR, Beck PL, and Muruve DA. The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. Journal of the American Society of Nephrology : JASN. 2010;21(10):1732-44.

10. Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, and Beck PL. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflammatory bowel diseases. 2011;17(6):1359-72.

11. McDonald B, Pittman K, Menezes GB, Hirota SA, Slaba I, Waterhouse CC, Beck PL, Muruve DA, and Kubes P. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science (New York, NY). 2010;330(6002):362-6.

12. Anders HJ, and Muruve DA. The inflammasomes in kidney disease. Journal of the American Society of Nephrology : JASN. 2011;22(6):1007-18.

13. Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, Bracey NA, Trpkov K, Bonni S, Duff HJ, Beck PL, and Muruve DA. Inflammasome-independent NLRP3 augments TGF-beta signaling in kidney epithelium. Journal of immunology (Baltimore, Md : 1950). 2013;190(3):1239-49.

14. Chung H, Ramachandran R, Hollenberg MD, and Muruve DA. Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-beta receptor signaling pathways contributes to renal fibrosis. The Journal of biological chemistry. 2013;288(52):37319-31.

15. Bracey NA, Duff HJ, and Muruve DA. Hierarchical regulation of wound healing by NOD-like receptors in cardiovascular disease. Antioxidants & redox signaling. 2015;22(13):1176-87.

16. Chun J, Chung H, Wang X, Barry R, Taheri ZM, Platnich JM, Ahmed SB, Trpkov K, Hemmelgarn B, Benediktsson H, James MT, and Muruve DA. NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy. Scientific reports. 2016;6(24667.

17. Chung H, Vilaysane A, Lau A, Stahl M, Morampudi V, Bondzi-Simpson A, Platnich JM, Bracey NA, French MC, Beck PL, Chun J, Vallance BA, and Muruve DA. NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell death and differentiation. 2016;23(8):1331-46.

18. Muruve DA, Mann MC, Chapman K, Wong JF, Ravani P, Page SA, and Benediktsson H. The biobank for the molecular classification of kidney disease: research translation and precision medicine in nephrology. BMC nephrology. 2017;18(1):252.

19. Komada T, Chung H, Lau A, Platnich JM, Beck PL, Benediktsson H, Duff HJ, Jenne CN, and Muruve DA. Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD. Journal of the American Society of Nephrology : JASN. 2018;29(4):1165-81.

20. Lau A, Chung H, Komada T, Platnich JM, Sandall CF, Choudhury SR, Chun J, Naumenko V, Surewaard BG, Nelson MC, Ulke-Lemee A, Beck PL, Benediktsson H, Jevnikar AM, Snelgrove SL, Hickey MJ, Senger DL, James MT, Macdonald JA, Kubes P, Jenne CN, and Muruve DA. Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury. The Journal of clinical investigation. 2018;128(7):2894-913.

21. Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, and Muruve DA. Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell reports. 2018;25(6):1525-36.e7.

22. Choudhury SR, Babes L, Rahn JJ, Ahn BY, Goring KR, King JC, Lau A, Petri B, Hao X, Chojnacki AK, Thanabalasuriar A, McAvoy EF, Tabaries S, Schraeder C, Patel KD, Siegel PM, Kopciuk KA, Schriemer DC, Muruve DA, Kelly MM, Yipp BG, Kubes P, Robbins SM, and Senger DL. Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver. Cell. 2019;178(5):1205-21.e17.

23. Komada T, and Muruve DA. The role of inflammasomes in kidney disease. Nature reviews nephrology. 2019;15(8):501-20.

24. Platnich JM, and Muruve DA. NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways. Archives of biochemistry and biophysics. 2019;670:4-14.

25. Bracey NA, Platnich JM, Lau A, Chung H, Hyndman ME, MacDonald JA, Chun J, Beck PL, Girardin SE, Gordon PM, Muruve DA. Tissue-selective alternate promoters guide NLRP6 expression Life Sci Alliance. 2020 Dec 29;4(3):e202000897.

26. Chung H, Komada T, Lau A, Chappellaz M, Platnich JM, de Koning HD, Petri B, Luque Y, Walker S, Benediktsson H, Mesnard L, Chun J, Muruve DA. AIM2 Suppresses Inflammation and Epithelial Cell Proliferation during Glomerulonephritis. Journal of immunology. 2021 Dec 1;207(11):2799-2812.

27. Lau A, Rahn JJ, Chappellaz M, Chung H, Benediktsson H, Bihan D, von Mässenhausen A, Linkermann A, Jenne CN, Robbins SM, Senger DL, Lewis IA, Chun J, Muruve DA. Dipeptidase-1 Governs Renal Inflammation During Ischemia Reperfusion Injury. Science advances. 2022;8:eabm0142