Rianne Gorter

Biography

After completing my MD/PhD in the Netherlands, I moved to Calgary together with my husband. Coming from a very flat country (average elevation 30 meters), we feel very lucky to have world-class mountains in our backyard, and spend much of our free time hiking, camping and skiing. We also enjoy Calgary’s craft brewing scene, which recently inspired us to start brewing our own beer.

Publications

1. Gorter RP, Arreguin AJ, Oost W, de Jonge JC, Kampinga HH, Amor S, Colognato H, and Baron W. Unexpected remyelination in the absence of MMP7. Glia. 73:1288–1306. 2025.
2. Li C, Morch MT, Gorter RP, Lozinski B, Ghorbani S, Dong Y, Shen YA, Harp C, Zandee S, Klement W, Prat A, and Yong VW. Characterization of Bruton’s tyrosine kinase in lesions of multiple sclerosis and three of its models. Neurology: Neuroimmunology and Neuroinflammation. 12:e200413. 2025.
3. Stephenson EL, Jain RW, Ghorbani S, Gorter RP, D’Mello C, and Yong VW. Uncovering novel extracellular matrix transcriptome alterations in lesions of multiple sclerosis. International Journal of Molecular Sciences. 25(2):1240. 2024.
4. Gorter RP, and Baron W. Recent insights into astrocytes as therapeutic targets for demyelinating diseases. Current Opinion in Pharmacology. 65:102261. 2022.
5. Gorter RP, Dijksman NS, Baron W, and Colognato H. Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: workflow and practical tips. Methods in Cell Biology.168:103–123. 2022.
6. Charvet B, Pierquin J, Brunel J, Gorter RP, Quétard C, Horvat B, Amor S, Portoukalian J, and Perron H. Human endogenous retrovirus type W envelope from MS demyelinating lesions shows unique solubility and antigenic characteristics. Virologica Sinica. 36:1006–1012. 2021.
7. Gorter RP, and Baron W. Matrix metalloproteinases shape the oligodendrocyte niche during development and upon demyelination. Neuroscience Letters. 729:E. 2020.
8. Gorter RP, Stephenson J, Nutma E, Anink J, de Jonge JC, Baron W, Jahreiß MC, Belien JAM, van Noort JM, Mijnsbergen C, Aronica E, and Amor S. Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes. Neuropathology and Applied Neurobiology. 45:459–475. 2019.
9. Nutma E, Stephenson JA, Gorter RP, de Bruin J, Boucherie DM, Donat CK, Breur M, van der Valk P, Matthews PM, Owen DR, and Amor S. A quantitative neuropathological assessment of TSPO expression in multiple sclerosis. Brain. 142:3440–3455. 2019.
10. Gorter RP, Nutma E, Jahreiß MC, de Jonge JC, Quinlan R, van der Valk P, van Noort JM, Baron W, and Amor S. Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis. Clinical and Experimental Immunology. 194:137–152. 2018.
11. Wang P, Gorter RP, de Jonge JC, Nazmuddin M, Zhao C, Amor S, Hoekstra D, and Baron W. MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions. Glia. 66:1625–1643. 2018.
12. Bridel C, Koel-Simmelink MJA, Peferoen L, Derada Troletti C, Durieux S, Gorter RP, Nutma E, Gami P, Iacobaeus E, Brundin L, Kuhle J, Vrenken H, Killestein J, Piersma SR, Pham TV, De Vries HE, Amor S, Jimenez CR, and Teunissen CE. Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro. Neuropathology and Applied Neurobiology. 44:404–416. 2018.

Awards

• EndMS Postdoctoral Fellowship MS Canada
• Gemmy & Mibeth Tichelaar Award Dutch MS Society
• MD/PhD Scholarship University of Groningen