Publications

Want to read up on the studies that the Stroke and Cognition Research Group publishes?

Dr. Barber's publications are listed below!

Ganesh, A., Barber, P., Black, S., Corbett, D., Field, T., Frayne, R., Hachinski, V., Ismail, Z., Mai, L., McCreary, C., Sahlas, D., Sharma, M., Swartz, R., & Smith, E. (2025). Abstract TP39: A Phase 2a randomized controlled trial of once-daily versus twice-daily remote ischemic conditioning in vascular cognitive impairment (TRIC-VCI). Stroke, 56(Suppl_1). https://doi.org/10.1161/str.56.suppl_1.TP39

Khan, F., Yogendrakumar, V., Lun, R., Rochwerg, B., Tran, A., Ganesh, A., Barber, P., Barakhanov, K., Lioutas, V., Ogren, J., Ois, A., Giralt-Steinhauer, E., Leng, X., Tian, X., Leung, W. H. T., Verburgt, E., Verhoeven, J., De Leeuw, F.-E., Ildstad, F., … Hill, M. (2025). Abstract WP270: Prognostic Factors Associated with Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis. Stroke, 56(Suppl_1). https://doi.org/10.1161/str.56.suppl_1.WP270

Writing Committee for the PERSIST Collaborators, Khan, F., Yogendrakumar, V., Lun, R., Ganesh, A., Barber, P. A., Lioutas, V.-A., Vinding, N. E., Algra, A., Weimar, C., Ögren, J., Edwards, J. D., Swartz, R. H., Ois, A., Giralt-Steinhauer, E., Khanevski, A. N., Leng, X., Tian, X., Leung, T. W., … Hill, M. D. (2025). Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis. JAMA, 333(17), 1508. https://doi.org/10.1001/jama.2025.2033

Yu, A. Y. X., Vatanpour, S., Ganesh, A., Field, T. S., Barber, P. A., Choi, P. M. C., Buck, B., Kleinig, T., Molina, C. A., Campbell, B. C. V., Appireddy, R., Muir, K. W., Hill, M. D., Coutts, S. B., Salluzzi, M., Blenkin, N., Dueck, A., Doram, C., Zhang, Q., … De Queiroz, J. P. (2025). Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial. Journal of the American Heart Association, 14(9), e039154. https://doi.org/10.1161/JAHA.124.039154

Benali, F., Singh, N., Fladt, J., Jaroenngarmsamer, T., Bala, F., Ospel, J. M., Buck, B. H., Dowlatshahi, D., Field, T. S., Hanel, R. A., Peeling, L., Tymianski, M., Hill, M. D., Goyal, M., Ganesh, A., ESCAPE-NA1 Investigators, Barber, P. A., Smith, E. E., Bal, S., … Möhlenbruch, M. A. (2024). Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke. JAMA Network Open, 7(1), e2349628. https://doi.org/10.1001/jamanetworkopen.2023.49628

Charatpangoon, P., Delannoy, P., McDougall, C., Vega, F., Mohite, A., Barber, P., Menon, B. K., Ganesh, A., & MacDonald, M. E. (2024). Radiation Dose Reduction in Computed Tomography Perfusion of Acute Ischemic Stroke Patients Using a Denoising Autoencoder. 2024 IEEE International Symposium on Biomedical Imaging (ISBI), 1–5. https://doi.org/10.1109/ISBI56570.2024.10635381

Coutts, S. B., Ankolekar, S., Appireddy, R., Arenillas, J. F., Assis, Z., Bailey, P., Barber, P. A., Bazan, R., Buck, B. H., Butcher, K. S., Camden, M.-C., Campbell, B. C. V., Casaubon, L. K., Catanese, L., Chatterjee, K., Choi, P. M. C., Clarke, B., Dowlatshahi, D., Ferrari, J., … De Queiroz, J. P. (2024). Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial. The Lancet, 403(10444), 2597–2605. https://doi.org/10.1016/S0140-6736(24)00921-8

Fladt, J., Guo, J., Specht, J. L., Wang, M., Chan, L. L., Mctaggart, R., Buck, B. H., Aviv, R., Swartz, R. H., Field, T. S., Tarpley, J., Shah, R., Goyal, M., Tymianski, M., Hill, M. D., Demchuk, A., d’Esterre, C., & Barber, P. (2024). Infarct Evolution on MR-DWI After Thrombectomy in Acute Stroke Patients Randomized to Nerinetide or Placebo: The REPERFUSE-NA1 Study. Neurology, 102(2), e207976. https://doi.org/10.1212/WNL.0000000000207976

Joundi, R. A., Smith, E. E., Mandzia, J., Ganesh, A., Menon, B. K., Rempel, J. L., Thornton, J., Roy, D., Jovin, T. G., Dowlatshahi, D., Frei, D. F., Bharatha, A., Poppe, A., Silver, F. L., Shuaib, A., Teitelbaum, J. S., Williams, D., Bang, O. Y., Sapkota, B. L., … for the ESCAPE Trial Investigators. (2024). Effect of Endovascular Thrombectomy for Acute Ischemic Stroke on Cognitive Outcomes: A Secondary Analysis of the ESCAPE Trial. Neurology, 102(10), e209270. https://doi.org/10.1212/WNL.0000000000209270

Singh, N., Kenney, C. C., Butcher, K. S., Buck, B., Barber, P. A., Field, T. S., Choi, P. M., Yu, A. Y., Kleinig, T., Appireddy, R., Molina, C. A., Muir, K. W., Hill, M. D., & Coutts, S. B. (2024a). A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial. International Journal of Stroke, 19(7), 817–822. https://doi.org/10.1177/17474930241253702

Singh, N., Kenney, C. C., Butcher, K. S., Buck, B., Barber, P. A., Field, T. S., Choi, P. M., Yu, A. Y., Kleinig, T., Appireddy, R., Molina, C. A., Muir, K. W., Hill, M. D., & Coutts, S. B. (2024b). A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial. International Journal of Stroke, 19(7), 817–822. https://doi.org/10.1177/17474930241253702

Tadros, G. S., Guo, J., Reaume, N., Towlson, E. K., & Barber, P. A. (2024). Abstract 70: Rich-Club Behaviour and Analyses in the Human Brain Connectome as Novel Early Biomarkers of Cognitive Decline. Stroke, 55(Suppl_1). https://doi.org/10.1161/str.55.suppl_1.70

Tadros, G. S., Sheronick, R., McDougall, C. C., & Barber, P. A. (2024). Abstract TMP59: Automated Analysis of Dynamic Computed Tomographic Angiography Perfusion Maps Accurately Identifies Regional Hypoperfusion in Minor Stroke Patients. Stroke, 55(Suppl_1). https://doi.org/10.1161/str.55.suppl_1.TMP59

Reid, M., Tadros, G. S., McDougall, C. C., Reaume, N., McDougall, B., Sah, R. G., Wang, M., Smith, E., Frayne, R., Coutts, S., Sajobi, T., Longman, S., D'Esterre, C., & Barber, P. (2023). Arterial spin labelling reveals multi-regional cerebral hypoperfusion in patients with transient ischemic attack that are unrelated to ischemia location: a proof-of-concept study. Cerebral Circulation-Cognition and Behavior, 4, 100164. https://doi.org/10.1016/j.cccb.2023.100164

Schaeffer, M. J., Reaume, N., Wang, M., Aftab, A., Pan, A., Tariq, S., Reid, R., Smith, E., D'Esteere, C., & Barber, P. A. (2023). Visualization of atrophy of medial temporal lobes and the septal nuclei in patients with transient ischaemic attack and controls. Cerebral Circulation-Cognition and Behavior, 5, 100177. https://doi.org/10.1016/j.cccb.2023.100177

Reaume N, Reid M, Tadros GS, Chacinski D, Denroche B, Aftab A, Wu P, Gupta Sah R, Wang M, Smith EE, Frayne R, Coutts SB, Sajobi T, Longman S, Ganesh A and Barber PA (2023). The relationship of small vessel disease burden on cerebral and regional brain atrophy rates and cognitive performance over one year of follow-up after transient ischemic attack. Front. Neurol. 14, 1277765. doi: 10.3389/fneur.2023.1277765

Black, S. A., Stepanchuk, A. A., Templeton, G. W., Hernandez, Y., Ota, T., Roychoudhury, S., ... & Tsutsui, S. (2022). Diagnosing Alzheimer’s Disease from Circulating Blood Leukocytes Using a Fluorescent Amyloid Probe. Journal of Alzheimer’s Disease, 85(4), 1721-1734.

Fladt, J., Guo, J., Specht, J., Chan, L., d’Esterre, C., Hill, M. D., Demchuk, A. M., & Barber, P. A. (2022). Abstract 119: The Effect Of Neuroprotectant NA1 On Early Infarct Growth Following Endovascular Therapy: The REPERFUSE-NA1 Study. Stroke, 53(Suppl_1). https://doi.org/10.1161/str.53.suppl_1.119

Ganesh, A., & Barber, P. A. (2022). The Cognitive Sequelae of Transient Ischemic Attacks—Recent Insights and Future Directions. Journal of Clinical Medicine, 11(9), 2637. https://doi.org/10.3390/jcm11092637

Buck, B. H., Hill, M. D., Quinn, F. R., Butcher, K. S., Menon, B. K., Gulamhusein, S., Siddiqui, M., Coutts, S. B., Jeerakathil, T., Smith, E. E., Khan, K., Barber, P. A., Jickling, G., Reyes, L., Save, S., Fairall, P., Piquette, L., Kamal, N., Chew, D. S., Demchuk, A. M., … Exner, D. V. (2021). Effect of Implantable vs Prolonged External Electrocardiographic Monitoring on Atrial Fibrillation Detection in Patients With Ischemic Stroke: The PER DIEM Randomized Clinical Trial. JAMA, 325(21), 2160–2168. https://doi.org/10.1001/jama.2021.6128

Morrish, R. E., Joundi, R. A., d'Esterre, C. D., McDougall, C. C., Morrish, W. F., Barber, P. A., & Calgary Stroke Program (2021). Reversal of Bilateral Sudden Deafness with Thrombectomy. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1. Advance online publication. https://doi.org/10.1017/cjn.2021.14

Schaeffer, M. J., Chan, L., & Barber, P. A. (2021). The neuroimaging of neurodegenerative and vascular disease in the secondary prevention of cognitive decline. Neural regeneration research, 16(8), 1490–1499. https://doi.org/10.4103/1673-5374.303011

Singh, R. J., Doshi, D., & Barber, P. A. (2021). Hypoglycemia Causing Focal Cerebral Hypoperfusion and Acute Stroke Symptoms. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 48(4), 550–552. https://doi.org/10.1017/cjn.2020.246

Stepanchuk, A. A., Barber, P. A., Lashley, T., Joseph, J. T., & Stys, P. K. (2021). Quantitative detection of grey and white matter amyloid pathology using a combination of K114 and CRANAD-3 fluorescence. Neurobiology of disease, 161, 105540. Advance online publication. https://doi.org/10.1016/j.nbd.2021.105540

d'Esterre, C. D., Sah, R. G., Assis, Z., Talai, A. S., Demchuk, A. M., Hill, M. D., Goyal, M., Lee, T. Y., Forkert, N. D., & Barber, P. A. (2020). Defining reperfusion post endovascular therapy in ischemic stroke using MR-dynamic contrast enhanced perfusion. The British journal of radiology, 93(1116), 20190890. https://doi.org/10.1259/bjr.20190890

Lim, S. T., Thijs, V., Murphy, S., Fernandez-Cadenas, I., Montaner, J., Offiah, C., Marquardt, L., Kelly, P. J., Bath, P. M., Lim, S. Y., Ford, G. A., Norrving, B., Cox, D., Prodan, C. I., Barber, P. A., Werring, D. J., Perry, R., Zgaga, L., Dawson, J., & McCabe, D. (2020). Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis. Journal of neurology, 267(10), 3021–3037. https://doi.org/10.1007/s00415-020-09932-y

McDougall, C. C., Chan, L., Sachan, S., Guo, J., Sah, R. G., Menon, B. K., Demchuk, A. M., Hill, M. D., Forkert, N. D., d'Esterre, C. D., & Barber, P. A. (2020). Dynamic CTA-Derived Perfusion Maps Predict Final Infarct Volume: The Simple Perfusion Reconstruction Algorithm. AJNR. American journal of neuroradiology, 41(11), 2034–2040. https://doi.org/10.3174/ajnr.A6783

Sah, R. G., Nobakht, S., Rajashekar, D., Mouches, P., Forkert, N. D., Sitaram, A., Tsang, A., Hill, M. D., Demchuk, A. M., d'Esterre, C. D., & Barber, P. A. (2020). Temporal evolution and spatial distribution of quantitative T2 MRI following acute ischemia reperfusion injury. International journal of stroke : official journal of the International Stroke Society, 15(5), 495–506. https://doi.org/10.1177/1747493019895673

Tariq, S., Sah, R. G., Chan, L., Rajashekar, D., McTaggart, R., Butcher, K., Aviv, R., Swartz, R., Field, T., Tarpley, J., Shah, R., Hill, M., Demchuk, A., Goyal, M., d'Esterre, C. D., & Barber, P. A. (2020). Recanalization following Endovascular treatment and imaging of PErfusion, Regional inFarction and atrophy to Understand Stroke Evolution-NA1 (REPERFUSE-NA1). International journal of stroke : official journal of the International Stroke Society, 15(3), 343–349. https://doi.org/10.1177/1747493019895666

Tariq, S., Tsang, A., Wang, M., Reaume, N., Carlson, H., Sajobi, T. T., Longman, R. S., Smith, E. E., Frayne, R., d'Esterre, C. D., Coutts, S. B., & Barber, P. A. (2020). White matter tract microstructure and cognitive performance after transient ischemic attack. PloS one, 15(10), e0239116. https://doi.org/10.1371/journal.pone.0239116

Campbell, B., Ma, H., Ringleb, P. A., Parsons, M. W., Churilov, L., Bendszus, M., Levi, C. R., Hsu, C., Kleinig, T. J., Fatar, M., Leys, D., Molina, C., Wijeratne, T., Curtze, S., Dewey, H. M., Barber, P. A., Butcher, K. S., De Silva, D. A., Bladin, C. F., Yassi, N., … EXTEND, ECASS-4, and EPITHET Investigators (2019). Extending thrombolysis to 4·5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data. Lancet (London, England), 394(10193), 139–147. https://doi.org/10.1016/S0140-6736(19)31053-0

Munir, M., Ursenbach, J., Reid, M., Gupta Sah, R., Wang, M., Sitaram, A., Aftab, A., Tariq, S., Zamboni, G., Griffanti, L., Smith, E. E., Frayne, R., Sajobi, T. T., Coutts, S. B., d'Esterre, C. D., Barber, P. A., & Alzheimer's Disease Neuroimaging Initiative (2019). Longitudinal Brain Atrophy Rates in Transient Ischemic Attack and Minor Ischemic Stroke Patients and Cognitive Profiles. Frontiers in neurology, 10, 18. https://doi.org/10.3389/fneur.2019.00018

Sah, R. G., d'Esterre, C. D., Hill, M. D., Hafeez, M., Tariq, S., Forkert, N. D., Demchuk, A. M., Goyal, M., & Barber, P. A. (2019). Diffusion-Weighted MRI Stroke Volume Following Recanalization Treatment is Threshold-Dependent. Clinical neuroradiology, 29(1), 135–141. https://doi.org/10.1007/s00062-017-0634-4

Sah, R. G., d'Esterre, C. D., Hill, M. D., Hafeez, M., Tariq, S., Forkert, N. D., Frayne, R., Demchuk, A. M., Goyal, M., & Barber, P. A. (2019). Diffusion-weighted imaging lesion growth occurs despite recanalization in acute ischemic stroke: Implications for future treatment trials. International journal of stroke : official journal of the International Stroke Society, 14(3), 257–264. https://doi.org/10.1177/1747493018798550

Evans, J. W., Graham, B. R., Pordeli, P., Al-Ajlan, F. S., Willinsky, R., Montanera, W. J., Rempel, J. L., Shuaib, A., Brennan, P., Williams, D., Roy, D., Poppe, A. Y., Jovin, T. G., Devlin, T., Baxter, B. W., Krings, T., Silver, F. L., Frei, D. F., Fanale, C., Tampieri, D., … ESCAPE Trial Investigators (2018). Time for a Time Window Extension: Insights from Late Presenters in the ESCAPE Trial. AJNR. American journal of neuroradiology, 39(1), 102–106. https://doi.org/10.3174/ajnr.A5462

Menon, B. K., Al-Ajlan, F. S., Najm, M., Puig, J., Castellanos, M., Dowlatshahi, D., Calleja, A., Sohn, S. I., Ahn, S. H., Poppe, A., Mikulik, R., Asdaghi, N., Field, T. S., Jin, A., Asil, T., Boulanger, J. M., Smith, E. E., Coutts, S. B., Barber, P. A., Bal, S., … INTERRSeCT Study Investigators (2018). Association of Clinical, Imaging, and Thrombus Characteristics With Recanalization of Visible Intracranial Occlusion in Patients With Acute Ischemic Stroke. JAMA, 320(10), 1017–1026. https://doi.org/10.1001/jama.2018.12498

Penn, A. M., Bibok, M. B., Saly, V. K., Coutts, S. B., Lesperance, M. L., Balshaw, R. F., Votova, K., Croteau, N. S., Trivedi, A., Jackson, A. M., Hegedus, J., Klourfeld, E., Yu, A., Zerna, C., Modi, J., Barber, P. A., Hoag, G., Borchers, C. H., & SpecTRA study group (2018). Validation of a proteomic biomarker panel to diagnose minor-stroke and transient ischaemic attack: phase 2 of SpecTRA, a large scale translational study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 23(8), 793–803. https://doi.org/10.1080/1354750X.2018.1499130

Tariq, S., & Barber, P. A. (2018). Dementia risk and prevention by targeting modifiable vascular risk factors. Journal of neurochemistry, 144(5), 565–581. https://doi.org/10.1111/jnc.14132

Tariq, S., d'Esterre, C. D., Sajobi, T. T., Smith, E. E., Longman, R. S., Frayne, R., Coutts, S. B., Forkert, N. D., & Barber, P. A. (2018). A longitudinal magnetic resonance imaging study of neurodegenerative and small vessel disease, and clinical cognitive trajectories in non demented patients with transient ischemic attack: the PREVENT study. BMC geriatrics, 18(1), 163. https://doi.org/10.1186/s12877-018-0858-4

Caldwell, J., Heran, M., McGuinness, B., & Barber, P. A. (2017). Imaging in acute ischaemic stroke: pearls and pitfalls. Practical neurology, 17(5), 349–358. https://doi.org/10.1136/practneurol-2016-001569