The World under a Microscope

Optimal Processing and Good Practice Techniques are Critical to Obtaining High-quality Sections

Professional Histology Services

At the Applied Spatial Omics Centre (ASOC), we offer comprehensive histology services to support advanced spatial transcriptomics platforms, including Visium and Xenium from 10X Genomics, and GeoMx and CosMx from NanoString. Our services are designed to provide precise tissue preparation and sectioning, essential for generating high-quality spatial data.

histology illustration

Core Services

Our histology services are structured to ensure the highest quality for your spatial transcriptomic projects:

Tissue embedding and sectioning

We provide expert tissue embedding and precise cryo- or paraffin-sectioning services, producing high-quality sections ideal for spatial transcriptomics. Each section is carefully prepared to maintain both tissue morphology and molecular integrity.

Histological support for Spatial Omics platforms

We ensure tissues are processed, sectioned, and placed on specialized slides to fit the platform's specifications. We specialize in preparing tissue sections for this high-resolution spatial molecular imaging platform, ensuring your tissues are optimized for multiplexed gene and protein analysis at single-cell resolution. These combined services ensure compatibility and optimal results across these leading spatial platforms, allowing for the seamless integration of transcriptomics, molecular imaging, and spatial profiling.

Specialized Immunohistochemistry

In addition to supporting spatial transcriptomics workflows, we offer advanced immunohistochemistry (IHC) and multiplex IHC (mIHC) services. These techniques provide complementary data on protein expression, adding another layer of molecular insight to your spatial analysis.

Histology Training Sessions for Trainees

To support researchers, ASOC provides histology training sessions that offer hands-on tissue preparation experience.

  • Tissue Processing Basics: Learn the essentials of tissue fixation, embedding, and sectioning, with a focus on fresh frozen and FFPE (formalin-fixed paraffin-embedded) samples.
  • Cryosectioning and Microtome Use: Gain practical skills in cryosectioning and microtome operation to produce precise sections required for each experiment.
  • Immunohistochemistry Techniques: Practical training in IHC and mIHC methods for protein visualization in tissue samples, enhancing spatial transcriptomic data with protein expression analysis.
  • Quality Control and Troubleshooting: Learn to assess the quality of tissue sections and resolve common issues to ensure that samples meet the rigorous standards required for spatial transcriptomic analysis.

Why Choose ASOC for Histology Services and Training?

  • Expertise Across Multiple Platforms: Our team has extensive experience in processing samples for Visium, Xenium, GeoMx, and CosMx platforms, ensuring high-quality data output for your research.
  • Hands-On Training for Trainees: We offer practical training sessions to help you master tissue sectioning and preparation techniques tailored to the latest spatial biology technologies.
  • Custom Protocol Development: We work closely with you to customize histology protocols that are aligned with the specific needs of your project and spatial platform.

For more information on our histology services or to inquire about upcoming training sessions, please contact us. We're here to support both your research and training in the rapidly evolving field of spatial biology.