Resources

This webinar was held by the Alzheimer Society of Alberta & Northwest Territories (ASANT) on Jun 10, 2020, and featured Dr. Marc Poulin and Dr. Veronica Guadagni.

The webinar focused on risk factors related to dementia, specifically the role of exercise, sleep, and brain blood flow in promoting cognitive health and preventing decline.

This article from the Cambridge Cognition Blog features lab members Dr. Matiram Pun and Dr. Veronica Guadagni discussing their published work on how different exposures to high altitude affect cognitive function.

• Guadagni et al. 2020. Aerobic exercise improves cognition and cerebrovascular regulation in older adults. Neurology. https://pubmed.ncbi.nlm.nih.gov/32404355/
• Guadagni et al. 2020. Association of Sleep Spindle Characteristics with Executive Functioning in Healthy Sedentary Middle-Aged and Older Adults. J Sleep Res. https://pubmed.ncbi.nlm.nih.gov/32281182/
• Rytz et al. 2020. Impact of Aerobic Exercise, Sex, and Metabolic Syndrome on Markers of Oxidative Stress: Results from the Brain in Motion Study. J Appl Physiol. https://pubmed.ncbi.nlm.nih.gov/32105521/
• Clark et al. 2019. Effect of Aerobic Exercise on White Matter Microstructure in the Aging Brain. Behav Brain Res. https://pubmed.ncbi.nlm.nih.gov/31279793/
• Drogos et al. 2019. Aerobic Exercise Increases Cortisol Awakening Response in Older Adults. Psychoneuroendocrinology. https://pubmed.ncbi.nlm.nih.gov/30721838/
• Hall et al. 2019. Novel Approach to Characterize Heterogeneity in an Aerobic Exercise Intervention. Med Sci Sports Exerc. https://pubmed.ncbi.nlm.nih.gov/30694976/
• Garber et al. 2018 Association between glycemic load and cognitive function in community-dwelling older adults: Results from the Brain in Motion study. Clin Nutr https://pubmed.ncbi.nlm.nih.gov/28756038/
• Guadagni et al. 2018. Effects of Six-Month Aerobic Exercise Intervention on Sleep in Healthy Older Adults in the Brain in Motion Study: A Pilot Study. J Alzheimers Dis Rep. https://pubmed.ncbi.nlm.nih.gov/30599044/  
• Tyndall et al. 2018. Protective Effects of Exercise on Cognition and Brain Health in Older Adults. Exerc Sport Sci Rev, 46(4). https://pubmed.ncbi.nlm.nih.gov/30001269/
• Pannu et al. 2017. Medication use by middle-aged and older participants of an exercise study: Results from the Brain in Motion study. BMC Complement Altern Med, 17(1). https://pubmed.ncbi.nlm.nih.gov/28187744/
• Drogos et al. 2016. Evidence of an association between sleep quality and APOE e4 in healthy older adults: A pilot study. https://pubmed.ncbi.nlm.nih.gov/27777343/
• Jackson et al. 2016. Promoting brain health through exercise and diet in older adults: a physiological perspective. J Physiol 594(16). https://pubmed.ncbi.nlm.nih.gov/27524792/
• Tyndall et al. 2016. Cardiometabolic risk factors predict cerebrovascular health in older adults: results from the Brain in Motion study. Physiol Rep 4(8). https://pubmed.ncbi.nlm.nih.gov/27117804/
• Poulin, Eskes & Hill. 2016. Physical Activity vs Health Education for Cognition in Sedentary Older Adults. JAMA 315(4). https://pubmed.ncbi.nlm.nih.gov/26645310/
• Ishigami et al. 2015. The Attention Network Test-Interaction (ANT-I): reliability and validity in healthy older adults. Exp Brain Res 234(3). https://pubmed.ncbi.nlm.nih.gov/26813216/
• Spencer et al. 2015. Cerebrovascular Responsiveness to Hypercapnia is Stable over Six Months in Older Adults. PLoS One 10(11). https://pubmed.ncbi.nlm.nih.gov/26599343/
• Gill et al. 2015. Association between Lifetime Physical Activity and Cognitive Function in Middle-Aged and Older Community Dwelling Adults: Results from the Brain in Motion Study. J Int Neuropsychol Soc 21(10). https://pubmed.ncbi.nlm.nih.gov/26581793/
• Tyndall et al. 2013. The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults. BMC Geriatr. https://pubmed.ncbi.nlm.nih.gov/23448504/

• Pun M, Guadagni V, Drogos LL et al. Cognitive Effects of Repeated Acute Exposure to Very High Altitude Among Altitude-Experienced Workers at 5050 m. High Alt Med Biol. 2019. 20:361-374, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/31651199/.
• Pun M, Guadagni V, Bettauer KM et al. Effects of Cognitive Functioning of Acute, Subacute and Repeated Exposures to High Altitude. Front Physiol. 2018. 9:1131, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/30246787/.
• Pun M, Hartmann SE, Furian M et al. Effect of Acute, Subacute, and Repeated Exposure to High Altitude (5050 m) on Psychomotor Vigilance. Front Physiol. 2018. 9:677, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/29915546/
• Khalyfa A, Zhang C, Khalyfa AA et al. 2016 Effect of intermittent hypoxia on plasma exosomal miRNA signature and endothelial function in healthy adults. Sleep. 39(12):2077-2090, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/27634792/.
• Beaudin AE, Waltz X, Pun M et al. 2015. Inflammation does not contribute to respiratory plasticity following acute intermittent hypoxia exposure. Eur. Respir. J. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/26065565/.
• Dempsey JA, Powell FL, Bisgard GE et al. 2014. Role of Chemoreception in Cardio-Respiratory Acclimatization to and Deacclimatization from Hypoxia.  J. Appl. Physiol. 116(7):858-66. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/24371017/.
• Champod AS, Eskes GA, Foster GE et al. 2013. Effects of acute intermittent hypoxia on working memory in young healthy adults. Am. J. Resp. Crit. Care Med. 187:1148-1150. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/23675727/.
• Pialoux V, Foster GE, Ahmed SB et al. 2011. Losartan abolishes oxidative stress induced by intermittent hypoxia in humans, J. Physiol. 589.22: 5529-5537. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/21930596/.
• Beaudin AE, Brugniaux JV, Vöhringer M et al. 2011. Cerebral and coronary blood flow responses to euoxic hypercapnia and isocapnic hypoxia in humans. Am. J. Physiol Heart Circ. Physiol.  301(4):H1678-86. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/21724871/.

• Beaudin et al. 2019. Vascular responses to hypoxia are not impaired in obstructive sleep apnea patients free of overt cardiovascular disease. Exp Physiol 104:580-600, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/30697840/.
• Beaudin et al. 2017. Human cerebral blood flow control during hypoxia: focus on chronic pulmonary obstructive disease and obstructive sleep apnea. J Appl Physiol 123:1350-1361, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/28798199/.
• Beaudin et al. 2017. Impact of obstructive sleep apnea and intermittent hypoxia on cardiovascular and cerebrovascular regulation. Exp Physiol 102:743-763, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/28439921/.
• Waltz et al. 2016. Effects of continuous positive airway pressure and isocapnic-hypoxia on cerebral autoregulation in patients with obstructive sleep apnea. J Physiol 594:7089-7104, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/27644162/.
• Zalucky et al. 2015. Activation of the rennin-angiotensin system is determined by the severity of nocturnal hypoxemia independent of obesity in obstructive sleep apnea. Am J Respir Crit Care Med,  192(7):873-80. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/26102156/.
• Nicholl et al. 2014. Evaluation of CPAP therapy on rennin-angiotensin system activity in obstructive sleep apnea. Am. J. Respir. Crit. Care Med 190(5):572-80. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/25033250/.
• Beaudin et al. 2014. Cyclooxygenases 1 and 2 differentially regulate blood pressure and cerebrovascular responses to acute and chronic intermittent hypoxia: implications for sleep apnea. J. Am. Heart Assoc 3(3):e000875. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/24815497/.

• Brown et al. 2010. Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women. Neurobiol Aging 31:2047-2057, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/19111937/.
• Eskes et al. 2010. Contribution of physical fitness, cerebrovascular reserve and cognitive stimulation to cognitive function in post-menopausal women. Front Aging Neurosci. 2:1-7, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/21048898/.
• Pialoux et al. 2009. Effect of cardiorespiratory fitness on vascular regulation and oxidative stress in postmenopausal women. Hypertension. 54:1014-1020, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/19786647/.
• Davenport et al. 2012. Ventilatory responses to exercise and CO2 after menopause in healthy women: effects of age and fitness. Respir Physiol Neurobiol. 184:1-8, https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/22750571/.

• Pialoux et al. 2017 Cyclooxygenase-2 inhibition prevents angiotensin II-induced DNA oxidation and protein nitration in humans. Frontiers in Physiology. 10:8(138). https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/28344559/.
• Yang et al. 2015. Studying cerebral hemodynamics and metabolism using simultaneous near-infrared spectroscopy and transcranial Doppler ultrasound: A hyperventilation and caffeine study. Physiol Reports. 2015 Apr;3(4).
• Kostoglou et al. 2014. Multivariate nonstationary modeling of cerebral hemodynamics. Conf. Proc. IEEE Eng. Med. Biol. Soc 2014:6028-31. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/25571371/.
• Fluck et al. 2014. Effects of aging on the association between cerebrovascular responses to visual stimulation, hypercapnia and arterial stiffness. Frontiers in Physiology - Integrative Physiology (Published Feb 19, 2014 doi:10.3389/fphys.2014.00049. eCollection 2014). 
• Kostoglou et al. 2014. Nonstationary multivariate modeling of cerebral autoregulation during hypercapnia. Medical Engineering & Physics. 2014 May; 36(5):592-600.
• Peca et al. 2013. Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy. Neurology 81(19):1659-65. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/24097810/.
• Davenport et al. 2012. Cerebrovascular reserve: an important link between fitness and cognitive function. Exercise and Sport Science Reviews. 40(3):153-158. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/22504726/.
• Debert, Ide, Poulin. 2012. Effects of estrogen and progesterone on cerebrovascular responses to euoxic Hypercapnia in women. Climacteric. 15(6):621-631. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/22208821/.
• Steinback, Whitelaw, Poulin. 2011. Hyperpnea not hypocapnia affects airway resistance in normal humans. Respir. Physiol. Neurobiol. 177:127-132. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/21457801/.

• Hartmann et al. 2015. Increased ventilatory response to hyperoxic-hypercapnia in COPD patients following vitamin C administration. European Respiratory Journal Open Research 15;1(1). https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/27730137/.
• Hartmann et al. 2015. Blood flow during handgrip exercise in COPD: effect of vitamin C. Medicine & Science in Sports & Exercise 48(2):200-9. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/26339724/.
• Hartmann et al. 2015. Cerebrovascular and ventilatory responses to acute isocapnic hypoxia in healthy aging and COPD: effect of vitamin C. J. Appl. Physiol 119(4):363-73. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/26089546/.
• Hartmann, Leigh, Poulin. 2014. Cerebrovascular Responses to Submaximal Exercise in Women with COPD.  BMC Pulmonary Medicine 4(99). https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/24898136/.
• Hartmann, Pialoux, Leigh, Poulin. 2012. Decreased Cerebrovascular Response to CO2 in Postmenopausal Women with COPD: Role of Oxidative Stress. Eur. Respir. J. 40:1354-61. https://pubmed-ncbi-nlm-nih-gov.ezproxy.lib.ucalgary.ca/22496327/.