Kris Chadee

Associate Member

Kris Chadee

Kris Chadee, Ph.D.

Professor, Microbiology, Immunology & Infectious Diseases                                         

Tier 1 Canada Research Chair in Gastrointestinal Inflammation
Primary Member: Gastrointestinal Research Group
Associate Member: Inflammation Research Network and Bacterial Pathogenesis Research Group
Microbiology, Immunology & Infectious Diseases (MIID)
Address:  Room 1879 Health Sciences Centre
                   3330 Hospital Drive N.W., Calgary, AB  T2N 4N1
Phone:  (403) 210-3975
Fax:  (403) 210-7882
Email: kchadee@ucalgary.ca

Curriculum Vitae:
PhD McGill University, 1985
MSc University of Manitoba, 1981
BSc University of Winnipeg, 1977

Potential Graduate Supervisor

Research

A major effort underway in our laboratory is to understand the mechanisms whereby infectious agents, lipid mediators of inflammation and cytokines modulate innate, immune and mucosal epithelial cell functions. Of particular interest to our group is the emerging concept that cross-talk between pathogen components and host cells or both, can predetermine the outcome of inflammatory or host defense mechanisms.  Consistent with this concept, our program of research is divided into three areas as follows:

1. To define the biochemical and molecular interactions by which the mucosal pathogen, E. histolytica trophozoites or its components can modulate epithelial barrier function in the gut.

2. To determine the molecular mechanisms by which PGE2 regulates IL-8 gene expression and protein production in human colonic epithelial cells.

3. To define the cellular and molecular basis by which E. histolytica adhesin, the Gal-lectin, can stimulate an effective cell-mediated immune response against ameba.

 

People

Graduate Trainees
Sharmin Begum (PhD) begums@ucalgary.ca
Steve Cornick (MSc) scornick@ucalgary.ca
Leanne Mortimer (PhD) lmmortim@ucalgary.ca
Jeanie Quach (PhD) jeanie.quach@ucalgary.ca
Adelaide Tawiah (PhD) aatawiah@ucalgary.ca
Christina Amat co-supervised (MSc/MD): ab.amat@ucalgary.ca

Postdoctoral Fellows
Manish Kumar manish.kumar@ucalgary.ca

Research Staff
France Moreau  fmoreau@ucalgary.ca