Wayne S.R. Chen

Professor

Physiology & Pharmacology

Professor

Department of Biochemistry & Molecular Biology

Member

Libin Cardiovascular Institute of Alberta

Molecular Biology and Disease

B.Sc. (Bachelor of Science) Ph.D. (Doctor of Philosophy)


Contact information

Location


Research and teaching

Research Activities

Research in my laboratory is directed towards understanding the structure/function relationships and physiological roles of the calcium release channel (ryanodine receptor) (RyR) in cardiac function. Our current research interests focus on: (i) the molecular and cellular basis of cardiac arrhythmia and sudden death, (ii) the molecular actions of pro- and anti-arrhythmic drugs and the development of novel anti-arrhythmic therapies, (iii) the molecular mechanisms of RyR activation by cytoplasmic and luminal calcium, (iv) regulation of RyR by phosphorylation, calmodulin and other protein regulators; and (v) three-dimensional structure of RyR. Techniques used in our studies include site-directed mutagenesis, single channel recordings in planar lipid bilayers, fluorescence Ca2+ imaging, purification of recombinant RyR proteins for biochemical and structural studies, cryo-electron microscopy, and gene targeting in mice.

Research Areas: 

Molecular Biology and Disease


Publications

PubMed