Karl T. Riabowol

Professor

Department of Biochemistry & Molecular Biology

Professor

Joint with Department of Oncology

Member

Arnie Charbonneau Cancer Institute

Member

Robson DNA Science Centre

Member

Alberta Children's Hospital Research Group

Associate Scientific Staff Member

Tom Baker Cancer Centre

Cell Signalling and Structure

Genomics Proteomics and Bioinformatics

Molecular Biology and Disease

B.Sc. (Bachelor of Science) Ph.D. (Doctor of Philosophy)


Contact information

Phone

Web presence

The Riabowol Lab

Location


Research and teaching

Research Activities

The Riabowol Laboratory studies the mechanisms that are critical for enforcing the state of cellular senescence in normal human cells and to determine how these mechanisms are eluded during the process of cancer cell immortalization. We examine the roles of telomeres, tumour suppressors and transcription factors in these processes and we discovered a novel tumour suppressor we called ING1 for INhibitor of Growth that is intimately involved in cell aging and immortalization. The five member ING gene family encodes >15 proteins produced by alternative splicing and promoter usage that contain PHD domains that specifically recognize the H3K4Me3 histone mark of active transcription. Recognition of H3K4Me3 allows them to read the histone code and subsequently target either histone acetyltransferase (HAT) or histone deacetylase (HDAC) complexes to regulate local chromatin structure and gene expression. A number of knockout models in different experimental systems are being developed to examine the contribution of telomeres to biological aging and the ING proteins to cell development and aging.

Research Areas: 

Cell Signalling and Structure

Genomics Proteomics and Bioinformatics

Molecular Biology and Disease

Research Personnel: 

  • Karen Blote, M.Sc., Technician
  • Dr. Whitney Alpaugh, Post Doctoral Fellow
  • Arthur Dantas, Ph.D. Graduate Student
  • Buthaina al Shueili, Ph.D. Graduate Student
  • Hari Thoppil, Ph.D. Ph.D. Graduate Student
  • Jessica Bertschmann, M.Sc. Graduate Student
  • Emily Doucette, Undergraduate Project Student
  • Benedicta Odame-Ankrah, Administrative Assistant

Publications

PubMed