Publications

ESCAPE

Demchuk AM, Goyal M, Menon BK, Eesa M, Ryckborst KJ, Kamal N, Patil S, Mishra S, Almekhlafi M, Randhawa PA, Roy D,Willinsky R, Montanera W, Silver FL, Shuaib A, Rempel J, Jovin T, Frei D, Sapkota B, Thornton MJ, Poppe A, Tampieri D, Lum C, Weill A, Sajobi TT, Hill MD for the ESCAPE Investigators. Endovascular treatment for Small Core and Anterior circulation Proximal occlusion with Emphasis on minimizing CT to recanalization times (ESCAPE) Trial: Methodology. International Journal of Stroke. 2014;10(3):429-438. doi: 10.1111/ijs.12424

Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA, Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Williams D, Bang OY, Baxter BW, Burns PA, Choe H, Heo J-H, Holmstedt CA, Jankowitz B, Kelly M, Linares G, Mandzia JL, Shankar J, Sohn S-I, Swartz RH, Barber PA, Coutts SB, Smith EE, Morrish WF, Weill A, Subramaniam S, Mitha AP, Wong JH, Lowerison MW, Sajobi TT, and Hill MD for the ESCAPE Trial Investigators. Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke. The New England Journal of Medicine. 2015;372(11):1019-1030. doi: 10.1056/NEJMoa1414905 

Sajobe TT, Zhang Y, Menon BK, Goyal M, Demchuk AM, Broderick JP, Hill MD. Effect Size Estimates for the ESCAPE Trial: Proportional Odds Regression Versus Other Statistical Methods. Stroke. 2015;46(7):1800-1805. doi: 10.1161/STROKEAHA.115.009328

TEMPO

Coutts SB, Dubuc V, Mandzia J, Kenney C, Demchuk AM, Smith EE, Subramaniam S, Goyal M, Patil S, Menon BK, Barber PA, Dowlatshahi D, Field T, Asdaghi N, Camden M-C, Hill MD for the TEMPO1 Investigators. Tenecteplase–Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke With Proven Occlusion. Stroke. 2015;46(3):769-774. doi: 10.1161/STROKEAHA.114.008504

Coutts SB, Hill MD. Response to Letter Regarding Article, "Tenecteplase-Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke with Proven Occlusion". Stroke. 2015;46(6):e150. doi: 10.1161/STROKEAHA.115.009240

ICH-ADAPT

Gioia LC, Kate M, Dowlatshahi D, Hill MD, Butcher K. Blood pressure management in acute intracerebral hemorrhage: current evidence and ongoing controversies. Current Opinion in Critical Care. 2015;21(2):99-106. doi: 10.1097/MCC.0000000000000182

Gioia LC, Kate M, McCourt R, Gould B, Coutts SB, Dowlatshahi D, Asdaghi N, Jeerakathil T, Hill MD, Demchuk AM, Buck B, Emery, D, Shuaib A, Butcher K for the ICH ADAPT Investigators. Perihematoma cerebral blood flow is unaffected by statin use in acute intracerebral hemorrhage patients. Journal of Cerebral Blood Flow and Metabolism. 2015;35:1175-1180. doi:10.1038/jcbfm.2015.36

McCourt R, Gould B, Kate M, Asdaghi N, Kosior JC, Coutts S, Hill MD, Demchuk A, Jeerakathil T, Emery D, Butcher K. Blood–Brain Barrier Compromise Does Not Predict Perihematoma Edema Growth in Intracerebral Hemorrhage. Stroke. 2015;46(4):954-960. doi: 10.1161/STROKEAHA.114.007544

Tsivgoulis G, Katsanos AH, Butcher K, Boviatsis E, Triantafyliou N, Rizos I, Alexandrov AV. Intensive blood pressure reduction in acute intracerebral hemorrhage. Neurology. 2014;83(17):1523-1529. doi:10.1212/WNL.0000000000000917

Choi V, Kate M, Kosior JC, Buck B, Steve T, McCourt R, Jeerakathil T,  Shuaib A, Emery D, Butcher K. National Institutes of Health Stroke Scale score is an unreliable predictor of perfusion deficits in acute stroke. International Journal of Stroke. 2015;10(4):582-588. doi: 10.1111/ijs.12438

Demchuk AM, Menon BK, Goyal M. Comparing Vessel Imaging: Noncontrast Computed Tomography/Computed Tomographic Angiography Should Be the New Minimum Standard in Acute Disabling Stroke. Stroke. 2016;47:00-00. doi: 10.1161/STROKEAHA.115.009171

Menon BK, Campbell BC, Levi C, Goyal M. Role of imaging in current acute ischemic stroke workflow for endovascular therapy. Stroke. 2015;46(6):1453-1461. doi: 10.1161/STROKEAHA.115.009160

Menon BK, d'Esterre CD, Qazi EM, Almekhlafi M, Hahn L, Demchuk AM, Goyal M. Multiphase CT Angiography: A New Tool for the Imaging Triage of Patients with Acute Ischemic Stroke. Radiology. 2015;275(2):510-520. doi: 10.1148/radiol.15142256

Menon BK, Qazi E, Nambiar V, Foster LD, Yeatts SD, Liebeskind D, Jovin TG, Goyal M, Hill MD, Tomsick TA, Broderick JP, Demchuk AM. Differential Effect of Baseline Computed Tomographic Angiography Collaterals on Clinical Outcome in Patients Enrolled in the Interventional Management of Stroke III Trial. Stroke. 2015;46(5):1239-1244. doi: 10.1161/STROKEAHA.115.009009

Acute stroke therapy

Ganesh A, Camden M, Lindsay P, Kapral MK, Cote R, Fang J, Zagorski B, Hill MD. The quality of treatment of hyperacute ischemic stroke in Canada: a retrospective chart audit. Canadian Medical Association Journal. 2015;2(4):E233-E239. doi: 10.9778/cmajo.20140067

Hill MD, Coutts SB. Alteplase in acute ischaemic stroke: the need for speed. The Lancet. 2014;384(9958):1904-1906. doi: http://dx.doi.org/10.1016/S0140-6736(14)60662-0

Sheth KN, Smith EE, Grau-Sepulveda MV, Kleindorfer D, Fonarow GC, Schwamm LH. Drip and ship thrombolytic therapy for acute ischemic stroke: use, temporal trends, and outcomes. Stroke. 2015;46(3):732-739. doi: 10.1161/STROKEAHA.114.007506

Yu AY, Hill MD, Coutts SB. Should minor stroke patients be thrombolyzed? A focused review and future directions. International Journal of Stroke. 2015;10(3):292-297. doi:10.1111/ijs.12426

Acute stroke visualization

Kamal N, Smith EE, Stephenson C, Choi PMC, Goyal M, Hill MD. Stroke. 2015;46(7):E170-E172. doi: 10.1161/STROKEAHA.115.009517

Endovascular stroke therapy

Goyal M, Menon BK, Hill MD, Demchuk AM. Consistently achieving computed tomography to endovascular recanalization. Stroke. 2014;45(12):E252-E256. doi:10.1161/STROKEAHA.114.007366

Hill MD, Goyal M, Demchuk AM. Endovascular stroke therapy - a new era. International Journal of Stroke. 2015;10(3):278-279. doi: 10.1111/ijs.12456

Khatri P, Hacke W, Fiehler J, Saver JL, Diener HC, Bendszus M, Bracard S, Broderick J, Campbell B, Ciccone A, Davalos A, Davis S, Demchuk AM, Dippel D, Donnan G, Fiorella D, Goyal M, Hill MD, Jauch EC, Jovin TG, Kidwell CS, Majoie C, Martins SCO, Mitchell P, Mocco J, Muir K, Nogueira RG, Schonewille WJ, Siddiqui AH, Thomalla G, Tomsick TA, Turk AS, While PM, Zaidat OO, Liebeskind DS, Fulton R, Lees KR. State of Acute Endovascular Therapy: Report From the 12th Thrombolysis, Thrombectomy, and Acute Stroke Therapy Conference. Stroke. 2015;46(6):1727-1734.doi: 10.1161/STROKEAHA.115.008782

Smith EE, Schwamm LH. Endovascular clot retrieval therapy: implications for the organization of stroke systems of care in North America. Stroke. 2015;46(6):1462-1467. doi: 10.1161/STROKEAHA.115.008385

Equipoise in Clinical Trials

Shamy MC, Stahnisch FW, Hill MD. Fallibility: a new perspective on the ethics of clinical trials enrollment. International Journal of Stroke. 2015;10(1):2-6. doi: 10.1111/ijs.12376

Predicting early recanalization

Ahn SH, d'Esterre CD, Qazi EM, Najm M, Rubiera M, Fainardi E, Hill MD, Goyal M, Demchuk AM, Lee TY, Menon BK. Occult Anterograde Flow Is an Under-Recognized but Crucial Predictor of Early Recanalization With Intravenous Tissue-Type Plasminogen Activator. Stroke. 2015;46(4):968-975. doi: 10.1161/STROKEAHA.114.008648

Reducing Door-to-Needle Time

Kamal N, Benavente O, Boyle K, Buck B, Butcher K, Casaubon  LK,  Côté R, Demchuk AM, Deschaintre Y, Dowlatshahi D, Gubitz GJ, Hunter G, Jeerakathil T, Jin A, Lang E, Lanthier S, Lindsay P, Newcommon N, Mandzia J, Norris CM, Oczkowski W, Odier C, Phillips S, Poppe AY,  Saposnik G, Selchen D, Shuaib A, Silver F, Smith EE, Stotts G, Suddes M, Swartz RH, Teal P, Watson T, & Hill, MD. Good is not good enough: the benchmark stroke door-to-needle time should be 30 minutes. Canadian Journal of Neurological Sciences. 2014;41(06):694-696. doi:10.1017/cjn.2014.41 

Musuka TD, Wilton SB, Traboulsi M, and Hill MD. Diagnosis and management of acute ischemic stroke: speed is critical. Canadian Medical Association Journal. 2015;187(12):887-893.  doi:10.1503/cmaj.140355 

Smith EE. Door-to-Needle Times: Let's Not Leave Smaller Hospitals Behind. Stroke. 2015;46(5):1158-1159. doi: 10.1161/STROKEAHA.115.008974

Stroke guidelines

Bayley M, Phillips S, Lindsay MP, Gubitz G, Smith EE, Cote R, Hill MD. Striving for excellence: stroke guidelines are a crucial foundation. International Journal of Stroke. 2015;10(3):276-277. doi: 10.1111/ijs.12461

Coutts SB, Wein TH, Lindsay MP, Buck B, Cote R, Ellis P, Foley N, Hill MD, Jaspers S, Jin AY, Kwiatkowski B, MacPhail C, McNamara-Morse D, McMurtry MS, Mysak T, Pipe A, Silver K, Smith EE, Gubitz G, Heart and Stroke Foundation Canada Canadian Stroke Best Practices Advisory Committee. International Journal of Stroke. 2015;10(3):282-291. doi: 10.1111/ijs.12439

Menon BK,Saver JL, Goyal M, Nogueira R, Prabhakaran S, Liang L, Xian Y, Hernandez AF, Fonarow GC, Schwamm L, Smith EE. Trends in endovascular therapy and clinical outcomes within the nationwide Get With The Guidelines-Stroke registry. Stroke. 2015;46(4):989-995. doi: 10.1161/STROKEAHA.114.007542

TIA management and treatment

Asdaghi N, Coulter JI, Modi J, Camden MC, Qazi A, Goyal M, Rundek T, Coutts SB. Statin Therapy Does Not Affect the Radiographic and Clinical Profile of Patients with TIA and Minor Stroke. American Journal of Neuroradiology. 2015;36(6):1076-1080. doi: 10.3174/ajnr.A4257

Kamal N, Hill MD, Blacquiere DPV, Boulanger J-M, Boyle K, Buck B, Butcher K, Camden M-C, Casaubon LK, Cote R, Demchuk AM, Dowlatshahi D, Dubuc V, Field TS, Ghrooda E, Gioia L, Gladstone DJ, Goyal M, Gubitz GJ, Harris D, Hart RG, Hunter G, Jeerakathil T, Jin A, Khan K, Lang E, Lantheir S, Lindsay P, Mackey A, Mandzia J, Mehdiratta M, Minuk J, Ocakowski W, Odier C, Penn A, Perry J, Pettersen JA, Phillips SJ, Poppe AY, Saposnik G, Selchen D, Shamy M, Sharma M, Shoamanesh A, Shuaib A, Silver F, Stotts G, Swartz R, Tamoyo A, Teitelbaum J, Verrealt S, Wein T, Yip S, Coutts S. Rapid assessment and treatment of transienct ischemic attacks and minor stroke in Canadian emergency departments: time for a paradigm shift. Stroke. 2015. (released online before print) doi: 10.1161/STROKEAHA.115.010454

Yu AY, Coutts SB. Stroke: Risk assessment to prevent recurrence after mild stroke or TIA. Nature Reviews Neurology. 2015;11(3):131-133. doi: 10.1038/nrneurol.2015.16

Trends in stroke admissions

Kamal N, Lindsay MP, Cote R, Fang J, Kapral MK, Hill MD. Ten-year trends in stroke admissions and outcomes in Canada. Canadian Journal of Neurological Sciences. 2015;42(3):168-175.  doi: 10.1017/cjn.2015.20

Treatment of Stroke in Canadian Emergency Departments: Time to be Leaders

Harris DR, Lang ES, Perry JJ, Morrison LJ. Treatment of stroke in Canadian EDs: Time to be leaders. Canadian Journal of Emergency Medicine. 2016 Jul 5:1-3 doi: 10.1017/cem.2016.333