Bin Hu

Biography

Professor Hu was the founding member and head of Division of Translational Neuroscience. His research has extended from the fundamental science such as thalamocortical auditory cueing network, axonal mechanism of deep brain stimulation and dormant neuron model of autism, to technology innovations and social engineering. He has led three large-scale, public funded and million-dollar translational international programs that developed 2nd Generation wearable system and digital health platforms for the diagnosis, treatment and telehealth of Parkinson’s disease and other neurological disorder (known as Ambulosono-ACSCON project). Current research interests include: 1) Technological and social platforms for facilitating evidence-based trials of non-pharmaceutical interventions, 2) Re-thinking the role of multi-domain exercise and cognitive training in modifying motor and cognitive decline in neurodegenerative diseases and 3) Neurobiological circuits and system underlying music-induced paradoxical movement in PD.

The long-term objective of my research program is to develop, validate and implement new and practical technological tools, supported by neurobiology and causality-based scientific concepts and approaches that will transform the current landscape of non-pharmaceutical treatment and management of chronic illness in an aging society. More specifically, I am interested in the applications of 2nd generation wearable systems, causality analysis, and applications of instrumental learning and social engagement behavioural models in the design of new diagnostics and interventions.

Publications

Selected publications:

Mooney DM, Zhang L, Basile C, Senatorov VV, Ngsee J, Omar A, Hu B*. Distinct forms of cholinergic modulation in parallel thalamic sensory pathways. Proceedings of National Academy of Science USA. 2004 Jan 6; 101(1):320-4.

Chomiak T and Hu B*. Axonal and Somatic Filtering of Antidromically Evoked Cortical Excitation by Simulated Deep Brain Stimulation. Journal of Physiology, 2007 579(Pt 2):403-12.

Chomiak T and Hu B*. The Functional Architecture and Spike Timing Properties of Corticofugal Projections from Rat Ventral Temporal Cortex. Journal of Neurophysiology, J Neurophysiol 100: 327-335, 2008

Chomiak T and Hu B. What is the optimal value of the g-ratio for myelinated fibers in the rat CNS? PloSONE, 2009 4(11): e7754.

Chomiak T, Hu B**, Alterations of Neocortical Development and Maturation in Autism: Insight from valproic acid exposure and animal models of autism. Neurotoxicology and Teratology Volume: 36 Special Issue: SI Pages: 57-66 Published: MAR-APR 2013

Chomiak T, Watts A, Burt J, Camicioli R, Tan SN, McKeown MJ, Hu B**. Differentiating cognitive or motor dimensions associated with the perception of fall-related self-efficacy in Parkinson's disease. Nature Publication Journal Parkinsons Dis. 2018 Aug 20;4:26. doi: 10.1038/s41531-018-0059-z.

Hu B**, Chomiak T. Wearable technological platform for multidomain diagnostic and exercise interventions in Parkinson's disease. Int Rev Neurobiol. 2019;147:75-93. doi: 10.1016/bs.irn.2019.08.004. Epub 2019 Sep 16.