Research and Publications

List of publications that used the HBIAMP Core Facility

2022

  • Ghorbani, S., Jelinek, E., Jain, R. et al. Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination. Nat Commun 132445 (2022). https://doi.org/10.1038/s41467-022-30032-0
  • Wuerch E, Mishra M, Melo H, Ebacher V, Yong VW. Quantitative analysis of spinal cord neuropathology in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2022; 362:577777. https://doi:10.1016/j.jneuroim.2021.577777

2021

  • Teo, W.; Caprariello, A.; Morgan, M. L.; Luchicchi, A.; Schenk, G. J.; Joseph, J. T.; Geurts, J. J. G.; Stys, P. K. Nile Red Fluorescence Spectroscopy Reports Early Physicochemical Changes in Myelin with High Sensitivity. Proceedings of the National Academy of Sciences of the United States of America 2021, 118 (8), e2016897118. https://doi.org/10.1073/pnas.2016897118.
  • Dong, Y.; D’Mello, C.; Pinsky, W.; Lozinski, B. M.; Kaushik, D. K.; Ghorbani, S.; Moezzi, D.; Brown, D.; Melo, F. C.; Zandee, S.; Vo, T.; Prat, A.; Whitehead, S. N.; Yong, V. W. Oxidized Phosphatidylcholines Found in Multiple Sclerosis Lesions Mediate Neurodegeneration and Are Neutralized by Microglia. Nature Neuroscience 2021. https://doi.org/10.1038/s41593-021-00801-z.

2020

  • Sarkar, S.; Yang, R.; Mirzaei, R.; Rawji, K.; Poon, C.; Mishra, M. K.; Zemp, F. J.; Bose, P.; Kelly, J.; Dunn, J. F.; Yong, V. W. Control of Brain Tumor Growth by Reactivating Myeloid Cells with Niacin. Science Translational Medicine 2020, 12 (537), eaay9924. https://doi.org/10.1126/scitranslmed.aay9924.
  • Plemel, J. R.; Stratton, J. A.; Michaels, N. J.; Rawji, K. S.; Zhang, E.; Sinha, S.; Baaklini, C. S.; Dong, Y.; Ho, M.; Thorburn, K.; Friedman, T. N.; Jawad, S.; Silva, C.; Caprariello, A.; Hoghooghi, V.; Yue, J.; Jaffer, A.; Lee, K.; Kerr, B. J.; Midha, R.; Stys, P. K.; Biernaskie, J.; Yong, V. W. Microglia Response Following Acute Demyelination Is Heterogeneous and Limits Infiltrating Macrophage Dispersion. Science Advances 2020, 6 (3), eaay6324. https://doi.org/10.1126/sciadv.aay6324.
  • Khetani, S.; Yong, K. W.; Kollath, V. O.; Eastick, E.; Azarmanesh, M.; Karan, K.; Sen, A.; Sanati-Nezhad, A. Engineering Shelf-Stable Coating for Microfluidic Organ-on-a-Chip Using Bioinspired Catecholamine Polymers. Acs Applied Materials & Interfaces 2020, 12 (6), 6910–6923. https://doi.org/10.1021/acsami.9b20826.
  • Khetani, S.; Yong, K. W.; Guan, K.; Singh, A.; Phani, A.; Kollath, V. O.; Kim, S.; Karan, K.; Sen, A.; Sanati-Nezhad, A. UV-Triggered Polymerization of Polycatecholamines Enables the Production of Organ-on-Chips inside a Biosafety Cabinet. Applied Materials Today 2020, 20, 100721. https://doi.org/10.1016/j.apmt.2020.100721.

2019

  • Waldner, D. M.; Visser, F.; Fischer, A. J.; Bech-Hansen, N. T.; Stell, W. K. Avian Adeno-Associated Viral Transduction of the Postembryonic Chicken Retina. Translational Vision Science & Technology 2019, 8 (4), 1. https://doi.org/10.1167/tvst.8.4.1.
  • Sahu, G.; Wazen, R.-M.; Colarusso, P.; Chen, S. R. W.; Zamponi, G. W.; Turner, R. W. Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability. Cell Reports 2019, 28 (9), 2427-+. https://doi.org/10.1016/j.celrep.2019.07.075.
  • Poon, C. C.; Gordon, P. M. K.; Liu, K.; Yang, R.; Sarkar, S.; Mirzaei, R.; Ahmad, S. T.; Hughes, M. L.; Yong, V. W.; Kelly, J. J. P. Differential Microglia and Macrophage Profiles in Human IDH-Mutant and -Wild Type Glioblastoma. Oncotarget 2019, 10 (33), 3129–3143. https://doi.org/10.18632/oncotarget.26863.
  • Luo, T.; Oladosu, O.; Rawji, K. S.; Zhai, P.; Pridham, G.; Hossain, S.; Zhang, Y. Characterizing Structural Changes With Devolving Remyelination Following Experimental Demyelination Using High Angular Resolution Diffusion MRI and Texture Analysis. Journal of Magnetic Resonance Imaging 2019, 49 (6), 1750–1759. https://doi.org/10.1002/jmri.26328.
  • Kaushik, D. K.; Bhattacharya, A.; Mirzaei, R.; Rawji, K. S.; Ahn, Y.; Rho, J. M.; Yong, V. W. Enhanced Glycolytic Metabolism Supports Transmigration of Brain-Infiltrating Macrophages in Multiple Sclerosis. Journal of Clinical Investigation 2019, 129 (8), 3277–3292. https://doi.org/10.1172/JCI124012.
  • Chesnelong, C.; Hao, X.; Cseh, O.; Wang, A. Y.; Luchman, H. A.; Weiss, S. SLUG Directs the Precursor State of Human Brain Tumor Stem Cells. Cancers 2019, 11 (11), 1635. https://doi.org/10.3390/cancers11111635.
  • Almishri, W.; Shaheen, A. A.; Sharkey, K. A.; Swain, M. G. The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice. Frontiers in Immunology 2019, 10, 803. https://doi.org/10.3389/fimmu.2019.00803.
  • Agabalyan, N. A.; Sparks, H. D.; Tarraf, S.; Rosin, N. L.; Anker, K.; Yoon, G.; Burnett, L. N.; Nickerson, D.; Di Martino, E. S.; Gabriel, V. A.; Biernaskie, J. Adult Human Dermal Progenitor Cell Transplantation Modulates the Functional Outcome of Split-Thickness Skin Xenografts. Stem Cell Reports 2019, 13 (6), 1068–1082. https://doi.org/10.1016/j.stemcr.2019.10.011.

2018

  • R.; Biernaskie, J. Macrophages Regulate Schwann Cell Maturation after Nerve Injury. Cell Reports 2018, 24 (10), 2561-+. https://doi.org/10.1016/j.celrep.2018.08.004.
  • Stratton, J. A.; Assinck, P.; Sinha, S.; Kumar, R.; Moulson, A.; Patrick, N.; Raharjo, E.; Chan, J. A.; Midha, R.; Tetzlaff, W.; Biernaskie, J. Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST. Frontiers in Cellular Neuroscience 2018, 12, 356. https://doi.org/10.3389/fncel.2018.00356.
  • Stephenson, E. L.; Mishra, M. K.; Moussienko, D.; Laflamme, N.; Rivest, S.; Ling, C.-C.; Yong, V. W. Chondroitin Sulfate Proteoglycans as Novel Drivers of Leucocyte Infiltration in Multiple Sclerosis. Brain 2018, 141, 1094. https://doi.org/10.1093/brain/awy033.
  • Sharma, S.; Kim, L. H.; Mayr, K. A.; Elliott, D. A.; Whelan, P. J. Parallel Descending Dopaminergic Connectivity of A13 Cells to the Brainstem Locomotor Centers. Scientific Reports 2018, 8, 7972. https://doi.org/10.1038/s41598-018-25908-5.
  • Shah, P. T.; Stratton, J. A.; Stykel, M. G.; Abbasi, S.; Sharma, S.; Mayr, K. A.; Koblinger, K.; Whelan, P. J.; Biernaskie, J. Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function. Cell 2018, 173 (4), 1045-+. https://doi.org/10.1016/j.cell.2018.03.063.
  • Rawji, K. S.; Kappen, J.; Tang, W.; Teo, W.; Plemel, J. R.; Stys, P. K.; Yong, V. W. Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Aging Mice Visualized by Ex Vivo Live Multiphoton Imaging. Journal of Neuroscience 2018, 38 (8), 1973–1988. https://doi.org/10.1523/JNEUROSCI.2341-17.2018.
  • Poon, C. C.; Ebacher, V.; Liu, K.; Yong, V. W.; Kelly, J. J. P. Automated Slide Scanning and Segmentation in Fluorescently-Labeled Tissues Using a Widefield High-Content Analysis System. Jove-Journal of Visualized Experiments 2018, No. 135, e57440. https://doi.org/10.3791/57440.
  • Plemel, J. R.; Michaels, N. J.; Weishaupt, N.; Caprariello, A. V.; Keough, M. B.; Rogers, J. A.; Yukseloglu, A.; Lim, J.; Patel, V. V.; Rawji, K. S.; Jensen, S. K.; Teo, W.; Heyne, B.; Whitehead, S. N.; Stys, P. K.; Yong, V. W. Mechanisms of Lysophosphatidylcholine-Induced Demyelination: A Primary Lipid Disrupting Myelinopathy. Glia 2018, 66 (2), 327–347. https://doi.org/10.1002/glia.23245.
  • Mousseau, M.; Burma, N. E.; Lee, K. Y.; Leduc-Pessah, H.; Kwok, C. H. T.; Reid, A. R.; O’Brien, M.; Sagalajev, B.; Stratton, J. A.; Patrick, N.; Stemkowski, P. L.; Biernaskie, J.; Zamponi, G. W.; Salos, P.; McDougall, J. J.; Prescott, S. A.; Matyas, J. R.; Trang, T. Microglial Pannexin-1 Channel Activation Is a Spinal Determinant of Joint Pain. Science Advances 2018, 4 (8), eaas9846. https://doi.org/10.1126/sciadv.aas9846.
  • Mirzaei, R.; Sarkar, S.; Dzikowski, L.; Rawji, K. S.; Khan, L.; Faissner, A.; Bose, P.; Yong, V. W. Brain Tumor-Initiating Cells Export Tenascin-C Associated with Exosomes to Suppress T Cell Activity. Oncoimmunology 2018, 7 (10), e1478647. https://doi.org/10.1080/2162402X.2018.1478647.
  • Koblinger, K.; Jean-Xavier, C.; Sharma, S.; Fuzesi, L.; Young, L.; Eaton, S. E. A.; Kwok, C. H. T.; Bains, J. S.; Whelan, P. J. Optogenetic Activation of A11 Region Increases Motor Activity. Frontiers in Neural Circuits 2018, 12, 86. https://doi.org/10.3389/fncir.2018.00086.
  • Jensen, S. K.; Michaels, N. J.; Ilyntskyy, S.; Keough, M. B.; Kovalchuk, O.; Yong, V. W. Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1 Alpha. Cell Reports 2018, 24 (12), 3167–3179. https://doi.org/10.1016/j.celrep.2018.08.060.
  • Faissner, S.; Mahjoub, Y.; Mishra, M.; Haupeltshofer, S.; Hahn, J. N.; Gold, R.; Koch, M.; Metz, L. M.; Ben-Hur, T.; Yong, V. W. Unexpected Additive Effects of Minocycline and Hydroxychloroquine in Models of Multiple Sclerosis: Prospective Combination Treatment for Progressive Disease? Multiple Sclerosis Journal 2018, 24 (12), 1543–1556. https://doi.org/10.1177/1352458517728811.
  • Dalgarno, R.; Leduc-Pessah, H.; Pilapil, A.; Kwok, C. H. T.; Trang, T. Intrathecal Delivery of a Palmitoylated Peptide Targeting Y382-384 within the P2X7 Receptor Alleviates Neuropathic Pain. Molecular Pain 2018, 14, 1744806918795793. https://doi.org/10.1177/1744806918795793.
  • Chu, T.-H.; Cummins, K.; Stys, P. K. The Triple Monoamine Re-Uptake Inhibitor DOV 216,303 Promotes Functional Recovery after Spinal Cord Contusion Injury in Mice. Neuroscience Letters 2018, 675, 1–6. https://doi.org/10.1016/j.neulet.2018.03.050.
  • Biswabharati, S.; Jean-Xavier, C.; Eaton, S. E. A.; Lognon, A. P.; Brett, R.; Hardjasa, L.; Whelan, P. J. Orexinergic Modulation of Spinal Motor Activity in the Neonatal Mouse Spinal Cord. Eneuro 2018, 5 (5), UNSP e0226-18.2018. https://doi.org/10.1523/ENEURO.0226-18.2018.
  • Barrett, K. T.; Roy, A.; Rivard, K. B.; Wilson, R. J. A.; Scantlebury, M. H. Vagal TRPV1 Activation Exacerbates Thermal Hyperpnea and Increases Susceptibility to Experimental Febrile Seizures in Immature Rats. Neurobiology of Disease 2018, 119, 172–189. https://doi.org/10.1016/j.nbd.2018.08.004.

2017

  • Stratton, J. A.; Kumar, R.; Sinha, S.; Shah, P.; Stykel, M.; Shapira, Y.; Midha, R.; Biernaskie, J. Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve. Eneuro 2017, 4 (3), e0307. https://doi.org/10.1523/ENEURO.0307-16.2017.
  • Sahu, G.; Asmara, H.; Zhang, F.-X.; Zamponi, G. W.; Turner, R. W. Activity-Dependent Facilitation of Ca(V)1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons. Journal of Neuroscience 2017, 37 (46), 11255–11270. https://doi.org/10.1523/JNEUROSCI.0967-17.2017.
  • Plemel, J. R.; Caprariello, A. V.; Keough, M. B.; Henry, T. J.; Tsutsui, S.; Chu, T. H.; Schenk, G. J.; Klaver, R.; Yong, V. W.; Stys, P. K. Unique Spectral Signatures of the Nucleic Acid Dye Acridine Orange Can Distinguish Cell Death by Apoptosis and Necroptosis. Journal of Cell Biology 2017, 216 (4), 1163–1181. https://doi.org/10.1083/jcb.201602028.
  • Lim, E.-M. F.; Nakanishi, S. T.; Hoghooghi, V.; Eaton, S. E. A.; Palmer, A. L.; Frederick, A.; Stratton, J. A.; Stykel, M. G.; Whelan, P. J.; Zochodne, D. W.; Biernaskie, J.; Ousman, S. S. AlphaB-Crystallin Regulates Remyelination after Peripheral Nerve Injury. Proceedings of the National Academy of Sciences of the United States of America 2017, 114 (9), E1707–E1716. https://doi.org/10.1073/pnas.1612136114.
  • Lim, E.-M. F.; Musa, A.; Frederick, A.; Ousman, S. S. AlphaB-Crystallin Expression Correlates with Aging Deficits in the Peripheral Nervous System. Neurobiology of Aging 2017, 53, 138–149. https://doi.org/10.1016/j.neurobiolaging.2017.01.006.
  • Leduc-Pessah, H.; Weilinger, N. L.; Fan, C. Y.; Burma, N. E.; Thompson, R. J.; Trang, T. Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance. Journal of Neuroscience 2017, 37 (42), 10154–10172. https://doi.org/10.1523/JNEUROSCI.0852-17.2017.
  • Getz, A. M.; Xu, F.; Visser, F.; Persson, R.; Syed, N. I. Tumor Suppressor Menin Is Required for Subunit-Specific NAChR Alpha 5 Transcription and NAChR-Dependent Presynaptic Facilitation in Cultured Mouse Hippocampal Neurons. Scientific Reports 2017, 7, 1768. https://doi.org/10.1038/s41598-017-01825-x.
  • Faissner, S.; Mishra, M.; Kaushik, D. K.; Wang, J.; Fan, Y.; Silva, C.; Rauw, G.; Metz, L.; Koch, M.; Yong, V. W. Systematic Screening of Generic Drugs for Progressive Multiple Sclerosis Identifies Clomipramine as a Promising Therapeutic. Nature Communications 2017, 8, 1990. https://doi.org/10.1038/s41467-017-02119-6.
  • D’Mello, C.; Almishri, W.; Liu, H.; Swain, M. G. Interactions Between Platelets and Inflammatory Monocytes Affect Sickness Behavior in Mice With Liver Inflammation. Gastroenterology 2017, 153 (5), 1416-+. https://doi.org/10.1053/j.gastro.2017.08.011.
  • Chu, T.-H.; Cummins, K.; Sparling, J. S.; Tsutsui, S.; Brideau, C.; Nilsson, K. P. R.; Joseph, J. T.; Stys, P. K. Axonal and Myelinic Pathology in 5xFAD Alzheimer’s Mouse Spinal Cord. Plos One 2017, 12 (11), e0188218. https://doi.org/10.1371/journal.pone.0188218.
  • Burma, N. E.; Leduc-Pessah, H.; Trang, T. Genetic Deletion of Microglial Panx1 Attenuates Morphine Withdrawal, but Not Analgesic Tolerance or Hyperalgesia in Mice. Channels 2017, 11 (5), 487–494. https://doi.org/10.1080/19336950.2017.1359361.
  • Burma, N. E.; Bonin, R. P.; Leduc-Pessah, H.; Baimel, C.; Cairncross, Z. F.; Mousseau, M.; Shankara, J. V.; Stemkowski, P. L.; Baimoukhametova, D.; Bains, J. S.; Antle, M. C.; Zamponi, G. W.; Cahill, C. M.; Borgland, S. L.; De Koninck, Y.; Trang, T. Blocking Microglial Pannexin-1 Channels Alleviates Morphine Withdrawal in Rodents. Nature Medicine 2017, 23 (3), 355–360. https://doi.org/10.1038/nm.4281.
  • Baimel, C.; Lau, B. K.; Qiao, M.; Borgland, S. L. Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons. Cell Reports 2017, 18 (6), 1346–1355. https://doi.org/10.1016/j.celrep.2017.01.030.
  • Asmara, H.; Micu, I.; Rizwan, A. P.; Sahu, G.; Simms, B. A.; Zhang, F.-X.; Engbers, J. D. T.; Stys, P. K.; Zamponi, G. W.; Turner, R. W. A T-Type Channel-Calmodulin Complex Triggers Alpha CaMKII Activation. Molecular Brain 2017, 10, 37. https://doi.org/10.1186/s13041-017-0317-8.