When to Suspect Autoimmune Encephalitis
Clinical Presentation
Onset
Acute to subacute progressive neuropsychiatric presentation. It is important to note that some types of AIE can present with a chronic course including AIE associated with: Anti-LGI1 Ab, Anti-CASPR2 Ab, Anti-DPPX Ab or Anti-IgLON5 Ab.
Prodromal symptoms
Infectious prodrome days to weeks preceding neuropsychiatric presentation. Other non-specific symptoms including headache, fatigue, sleep, weight loss & early psychiatric manifestations
Risk Factors
Personal or family history of autoimmune diseases, infectious encephalitis and immune checkpoint inhibitors treatment